Tisi Renata Anita, PhD

Associate Professor in Molecular Biology



room 5017, building U4, tel. +39 02 6448 3522

lab 5044, building U4, tel. +39 02 6448 3534


The activity is focused on the following research lines

Health research area BtBs UNIMIB

Cancer, Drug Discovery and Pharmacology, Genetic Diseases, Neurodegenerative and neurological diseases, Systems biology

industrial biotechnology research area BtBs UNIMIB
Industrial Biotechnology

Molecular modeling and Structural Biology


Research group

Vertemara Jacopo – PostDoc
room 4064, building U3,  tel. +39 02 6448 3473, jacopo.vertemara@unimib.it


Homology modelling; Small molecule-protein docking; Protein-protein docking

Research areas

-Signal transduction
-Computational Biology
-Systems Biology
-Biological systems analysis, modelling and simulation

Selected publications

-Marsella A, Gobbini E, Cassani C, Tisi R, Cannavo E, Reginato G, Cejka P, Longhese MP. Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners. Cell Rep. 2021 Mar 30;34(13):108906. doi: 10.1016/j.celrep.2021.108906.

-Tisi R, Spinelli M, Palmioli A, Airoldi C, Cazzaniga P, Besozzi D, Nobile MS, Mazzoleni E, Arnhold S, De Gioia L, Grandori R, Peri F, Vanoni M, Sacco E. The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells. Front Mol Biosci. 2021 Feb 17;8:625979. doi: 10.3389/fmolb.2021.625979.

-Tisi R, Gaponenko V, Vanoni M, Sacco E. Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives. Biomolecules. 2020 Nov 10;10(11):1535. doi: 10.3390/biom10111535.

-Tisi R, Vertemara J, Zampella G, Longhese MP. Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks. Comput Struct Biotechnol J. 2020 May 16;18:1137-1152. doi: 10.1016/j.csbj.2020.05.013.

Tisi’s Lab – #TisiLab_BtBs
last update May 2021