Becchetti Andrea, PhD

Associate Professor of Physiology
Andrea Becchetti BtBs UNIMIB

 

room 3010, building U3, tel.: +39 02 6448 3301

lab 3041, building U3, tel. +39 02 6448 3311

andrea.becchetti@unimib.it

PudMed, Google Scholar

The activity is focused on the following research lines
Health research area BtBs UNIMIB
Health

Cancer, Genetic Diseases, Neurodegenerative and neurological diseases

Research group

Meneghini Simone – PostDoc
lab 3041, bulding U3, tel. +39 02 6448 3311, s.meneghini1@campus.unimib.it

Colombo Giulia – PhD Student
lab 3041, bulding U3, tel. +39 02 6448 3311, g.colombo83@campus.unimib.it

Keywords
Nicotinic receptors, epilepsy, sleep, hypocretin, cerebral cortex, synaptic transmission, cell adhesion, integrin receptors, potassium channels, hERG.

Background

Andrea Becchetti has received his academic degrees at the University of Milan. Next, he has spent prolonged research sojourns at the Department of General Pathology of the University of Florence (Italy), the Department of Physiology of the Emory University (Atlanta, USA), the Department of Physiological Sciences of the University of Newcastle upon Tyne (UK) and the Biophysics Sector of the International School for Advanced Studies (ISAS-SISSA), in Trieste (Italy). He is currently associate professor of General Physiology and Neuroscience.

Research areas

Cell physiology, Neurophysiology, Neuroscience.

Research interest

Andrea Becchetti’s current research interests include the nicotinic and hypocretinergic modulation of synaptic transmission in the mature and developing brain, the pathogenesis of sleep-related epilepsy, and the role of voltage-gated K+ channels in cell adhesion, migration and proliferation. We carry out functional studies by electrophysiological methods in single cells (patch-clamp) and neuronal networks (multi-array recording), coupled to biomolecular and morphological methods.

Research projects

Active projects

1) Cholinergic regulation of the prefrontal microcircuit in wild-type mice and murine models of sleep-related epilepsy: implications for the modulation of arousal and the sleep-waking cycle (in collaboration with Dr. Amadeo).

2) Functional study of mutant α2, α4 and β2 nicotinic subunits linked to sleep-related and other epilepsies.

3) Study of the effect of hypocretins/orexins on neuronal transmission in subcortical arousal nuclei and prefrontal cortex, in mice conditionally expressing hypocretin receptors (in collaboration with Dr. Vassalli).

4) Role of voltage-dependent K+ channels (especially KV11.1, also known as hERG1) in cell adhesion and proliferation of excitable and non excitable cells, including cancer (in collaboration with prof. Arcangeli).

Selected articles

1) Becchetti A, Petroni G, Arcangeli A. Ion channel conformations regulate integrin-dependent signaling. Trends Cell Biol 29: 298-307, 2019.

2) Amadeo A, Coatti A, Aracri P, Ascagni M, Iannantuoni D, Modena D, Carraresi L, Brusco S, Meneghini S, Arcangeli A, Pasini ME, Becchetti A. Postnatal changes in K+/Cl- cotransporter-2 expression in the forebrain of mice bearing a mutant nicotinic subunit linked to sleep-related epilepsy. Neuroscience 386: 91-107, 2018.

3) Becchetti A, Crescioli S, Zanieri F, Petroni G, Mercatelli R, Coppola S, Gasparoli L, D’Amico M, Pillozzi S, Crociani O, Stefanini M, Fiore A, Carraresi L, Morello V, Manoli S, Brizzi MF, Ricci D, Rinaldi M, Masi A, Schmidt T, Quercioli F, Defilippi P, Arcangeli A. The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression. Science Signaling 10: eaaf3236, 2017.

4) Aracri P, Banfi D, Pasini ME, Amadeo A, Becchetti A. Orexin (hypocretin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex. Cerebral Cortex 25: 1330-1347, 2015


Becchetti’s Lab – #BecchettiLab_BtBs
last update: September 2020