Zaza Antonio

Professor of Physiology
Antonio Zaza BtBs UNIMIB

 

room 3011, building U3, tel. +39 02 6448 3307

lab 3015, building U3, tel. +39 02 6448 3331

antonio.zaza@unimib.it

see also: ResearchGate

The activity is focused on the following research lines
Health research area BtBs UNIMIB
Health

Cardiovascular diseases, Drug Discovery and Pharmacology

Research group
GRUPPO 2019 Zaza BtBs UNIMIB

Camerlengo Davide – Master Student

lab 3015, building U3, tel. +39 6448 3331, d.camerlengo@campus.unimib.it

Lodola Francesco  – PostDoc

Badone Beatrice – PostDoc
lab 3015, building U3, tel. +39 6448 3331, b.badone@campus.unimib.it

Leone Jenny – Master Student
lab 3015, building U3, tel. +39 6448 3331, j.leone2@campus.unimib.it

Pane Doriana – Master Student
lab 3018, building U3, tel. +39 6448 3331, d.pane1@campus.unimib.it

Keywords
ion channels, excitation-contraction coupling, repolarization, arrhythmias

Background

Degree: Medicine/Cardiology; Research Assistant: Pharmacology, Columbia University (NY) (1986-1989); Professor of Physiology Univ Milano Bicocca (2000-); Hein Wellens Visiting Professor ; CARIM - Maastricht University (NL)(2017-2018). Fellow of the European Society of Cardiology (2015-) ; ESC Task-Force member (2019); Deputy Editor of Europace (2016-); Associate Editor of Frontiers (2018-) and J Cardiovasc Pharmacology (2010-).

Research interest

interaction between membrane electrophysiology and intracellular Ca2+ dynamics in arrhythmogenesis

Research areas

Cardiac electrophysiology, arrhythmias, heart failure

Research projects
Active projects

-Development of SERCA activating drugs for the treatment of heart failure and arrhythmias based on Ca2+ store instability (departmental collaboration)
-Pathophysiology of a phospholamban (PLN)  mutation (R14del) in patient-derived hiPS-CMs

Finished projects

-Pathophysiology of LQT-type calmodulin mutations in patient-derived hiPS-CMs
-Mechanisms of phenotypic modulation of LQT1 syndrome by gene modifiers in patient-derived hiPS-CMs

Selected articles

-Lee, Y. K., Sala, L., Mura, M., Rocchetti, M., Pedrazzini, M., Ran, X., . . . Gnecchi, M. (2020). MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes. Cardiovasc Res. doi:10.1093/cvr/cvaa019

-Ronchi, C., Bernardi, J., Mura, M., Stefanello, M., Badone, B., Rocchetti, M., . . . Zaza, A. (2020). NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis. Cardiovasc Res. doi:10.1093/cvr/cvaa036

-Brugada, J., Katritsis, D. G., Arbelo, E., Arribas, F., Bax, J. J., Blomstrom-Lundqvist, C., . . . Group, E. S. C. S. D. (2020). 2019 ESC Guidelines for the management of patients with supraventricular tachycardia; The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC). Eur Heart J, 41(5), 655-720. doi:10.1093/eurheartj/ehz467

-Rocchetti, M., Sala, L., Dreizehnter, L., Crotti, L., Sinnecker, D., Mura, M., . . . Zaza, A. (2017). Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res, 113(5), 531-541. doi:10.1093/cvr/cvx006

International and national collaborations

Dipartimento BTBS - Joint Lab initiative for the development of SERCA activators (Francesco Peri, Marcella Rocchetti, Mara Ferrandi, Paolo Barassi)

Peter J Schwartz- Lia Crotti: Center for Arrhythmias of Genetic Origin - Istituto Auxologico Italiano & Università Milano-Bicocca

Massimiliano Gnecchi - Dept of Molecular MedicineUniversità di Pavia

Thomas HeschenhagenArne Hansen: Pharmacology & Toxicology- Eppendorf University, Hamburg (DE)

Rudolph De Boer: Experimental Cardiology, Thorax centerUMCG- Groningen (NL)

Toon Van Veen-Jeroen Bakkers: Medical Physiology, University Medical Center, Utrecht (NL)


Zaza’s Lab – #ZazaLab_BtBs
last update: September 2020