Chiaradonna Ferdinando, PhD

Keywords
Basis of cancer, signal transduction, cell cycle, cell death, cancer metabolism, relationship between cell metabolism and cancer hallmarks, tumor metabolism inhibition, systems biology

Research interest

Role of metabolism in tumor growth, maintenance and resistance to chemotherapy

The activity is focused on the following research lines
Health research area BtBs UNIMIB
Health

Cancer, Drug Discovery and Pharmacology, Systems biology

Graphical abstract
graphical-abstract-Ferdinando-Chiaradonna-BtBs-UNIMIB

Research Group

Francesca Ricciardiello - PostDoc
lab 5048, building U4, tel. +39 02 6448 3558, francesca.ricciardiello@unimib.it

Roberta Palorini - PostDoc
lab 5048, building U4, tel. +39 02 6448 3558, roberta.palorini@unimib.it

Chiara Lattuada – Master student in Biology
lab 5048, building U4, tel. +39 02 6448 3558, c.lattuada1@campus.unimib.it

Francesca Mossi – Master student in Biotechnology

Research projects

2109-2021: Executive Programme of Scientific Collaboration between Italy and China, Innovative Biomedical Devices (BIOMED) 2019-2021 (Responsabile di Progetto), Preclinical evaluation of a PGM3 inhibitor as innovative therapeutic approach for pancreatic ductal adenocarcinoma finanziato dal Ministero Affari Esteri e Cooperazione Internazionale. Validazione preclinica in tumori pancreatici di un nuovo inibitore specifico della via delle esosammine e valutazione della sua capacità di inibire la resistenza dei tumori pancreatici alla gemcitabina.

Selected articles

- Ricciardiello F, Gang G, Palorini P, Li Q, Giampà M, Zhao F, You L, La Ferla B,  De Vitto H, Guan W,  Gu J, Zhang T, Zhao Y, Chiaradonna F*. Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through Unfolded Protein Response and EGFR-Akt pathway modulation. Oncogene. 2020 May;39(20):4103-4117. doi: 10.1038/s41388-020-1260-1. *Co-Corresponding Author

- Barilani M, Palorini R, Votta G, Piras R, Buono G, Grassi M, Bollati V, Chiaradonna F*, Lazzari L. Central metabolism of functionally heterogeneous mesenchymal stromal cells. Scientific Reports. 2019 Oct 28;9(1):15420. doi: 10.1038/s41598-019-51937-9 *Co-Corresponding Author

- Chiaradonna F*, Ricciardiello F, Palorini R. The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring. Cells. 2018 Jun 2;7(6):53. doi: 10.3390/cells7060053. *Corresponding Author

- Ricciardiello F, Votta G, Palorini R, Raccagni I, Brunelli L, Paiotta A, Tinelli F, D’Orazio G, Valtorta S, De Gioia L, Pastorelli R, Moresco RM, La Ferla B, Chiaradonna F*. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377. doi: 10.1038/s41419-018-0405-4. *Corresponding Author

International and national collaborations

- Prof. Taiping Zhang, Peking Union Medical College Hospital, Beijing, China; Institute of Materia Medica, Chinese Academy of medical Science, Beijing, China.

- Susanna Chiocca, Principal Investigator at European Institute of Oncology , Milan, Italy

- Alfonso Urbanucci, Principal Investigator at Institute for Cancer Research at Oslo University Hospital, Finland

- Andre Wegner, group leader of Pathometabolism group at BRICS (Braunschweig Integrated Centre of Systems Biology), University of Braunschweig, Germany

 


Chiaradonna’s Lab – #ChiaradonnaLab_BtBs
last update: October 2020