Salvioni Lucia, PhD

My research activity is devoted to the world of nanobiotechnology: this includes several multidisciplinary activities like the development of nanodrug delivery systems, the study of novel nano-based contrast agents, the formulation design as well as the investigation of interaction between nanomaterials and biological systems.

I am part of a multidisciplinary research group named NanoBioLab.
https://nanobiolab.it/ ; https://www.instagram.com/nanobiolab/

The activity is focused on the following research lines

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Health research area BtBs UNIMIB
Health

Nanomedicine and Biomaterials, Cancer, Inflammation and infections

Keywords

Nanomedicine, Nanobiotechnology, Nanomaterials, Drug delivery, Imaging, Formulations, Cancer, Infections and Inflammation

Research interest

Nanodelivery of biological drugs
Biological drugs include a wide range of active ingredients such as peptides, proteins, genetic materials, whose application is strongly impaired by their poor stability, low permeability and rapid body clearance. The use of nano-based drug delivery systems may overcome these drawbacks and open up new possibility for treatment of several disorders (e.g., cancer, infections, metabolic disorders).

Nanomaterials for diagnostic purposes
The early diagnosis is the key for successfully treating several disorders including cancer. One major need in the field of medical imaging is to increase the specificity and the sensitivity of contrast agents. In this scenario, engineered nanomaterials can be developed for directing contrast agents in specific regions and improve the detection of malignant masses.

Study of Nano-Bio Interactions
Several scientists have pointed out that lack of knowledge in the interaction of nanomaterials with biological systems can seriously limit nanotechnology potential. Thus, part of my research activity aims to give a contribution to this field by investigating nanoparticles intracellular trafficking, their capability of crossing the biological barriers, nanotoxicology or their potential antimicrobic effect.

Development of solid and semisolid formulations
The majority of the new products based on nanomaterials are administered by parenteral injection. However, the use of alternative administration routes may open up new possibilities and better meet the need of the patients in terms of compliance. Thus, part of my research activity is focused on the study of formulation of drug and nanodelivery systems in semisolid and solid dosage forms for pharmaceutical and cosmetic purposes.

Selected articles

Saporin Toxin Delivered by Engineered Colloidal Nanoparticles Is Strongly Effective against Cancer Cells
L. Salvioni, F Testa, L. Barbieri, M. Giustra, J. A. Bertolini, G. Tomaino, P. Tortora, D. Prosperi, M. Colombo
Pharmaceutics. 2022, 14 (7), 1517. https://doi.org/10.3390/pharmaceutics14071517

Development of an effective tumor-targeted contrast agent for Magnetic Resonance Imaging based on Mn/H-Ferritin nanocomplexes
C. Tullio†, L. Salvioni†, M. Bellini, A. Degrassi, L. Fiandra, S Garbujo, R. Rotem, F. Testa, D. Prosperi, M. Colombo
ACS applied biomaterials and interface.  2021, 4(11), 7800–7810. https://doi.org/10.1021/acsabm.1c00724

Impact of Tuning the Surface Charge Distribution on Colloidal Iron Oxide Nanoparticle Toxicity Investigated in Caenorhabditis elegans
L. Amigoni†, L. Salvioni†, B. Sciandrone, M. Giustra, C. Pacini, P. Tortora, D. Prosperi, M. Colombo, M.E. Regonesi. Nanomaterials. 2021, 11(6), 1551. https://doi.org/10.3390/nano11061551    

The emerging role of nanotechnology in skincare
L. Salvioni, L. Morelli, E. Ochoa, M. Labra, L. Fiandra, L. Palugan, D. Prosperi, M. Colombo
Advances in Colloid and Interface Science. 2021, 293. https://doi.org/10.1016/j.cis.2021.102437

Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment
L. Salvioni, S. Zuppone, F. Andreata, M. Monieri, S. Mazzucchelli, C. Di Carlo, L. Morelli, C. Cordiglieri, L. Donnici, R. De Francesco, F. Corsi, D. Prosperi, R. Vago, M. Colombo
Advanced Therapeutics. 2020, 3(8). https://doi.org/10.1002/adtp.202000007

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope
L. Salvioni†, M.A. Rizzuto†, J.A. Bertolini, L. Pandolfi, M. Colombo, D. Prosperi.
Cancers (Basel). 2019, 11(12). https://doi.org/10.3390/cancers11121855

Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations
L. Salvioni, E. Galbiati, V. Collico, G. Alessio, S. Avvakumova, F. Corsi, P. Tortora, D. Prosperi, M. Colombo.
International Journal of Nanomedicine. 2017, 12, 2517–2530. https://doi.org/10.2147/IJN.S127799

Oral delivery of insulin via polyethylene imine-based nanoparticles for colonic release allows glycemic control in diabetic rats
L. Salvioni, L. Fiandra, M.D. Del Curto, S. Mazzucchelli, R. Allevi, M. Truffi, L. Sorrentino, B. Santini, M. Cerea, L. Palugan, F. Corsi, M. Colombo.
Pharmacological Research. 2016, 110, 122–130, https://doi.org/10.1016/j.phrs.2016.05.016

† equally contributed


Salvioni’s Lab – #SalvioniLab_BtBs
last update: December
2022