Lodola Francesco, PhD

The activity is focused on the following research lines
Health research area BtBs UNIMIB

Cardiovascular disease, Drug Discovery and Pharmacology, Nanomedicine and biomaterials

Cardiovascular Physiology, intracellular Ca2+ signaling, excitation-contraction coupling, optical modulation, nanomaterials, nanomedicine, therapeutic angiogenesis.

Research interest

Intracellular Ca2+ cycling and signaling in cardiac arrhythmias; Therapeutic angiogenesis for the treatment of cardiovascular diseases; Novel approaches to control electrical activity and differentiation of cardiac cells.

Selected articles

* Co-first author , # Corresponding author

-DiFrancesco M.L., Lodola F.*, Colombo E., Maragliano L., Bramini M., Paternò G.M., Baldelli P., Della Serra M., Lunelli L., Marchioretto M., Grasselli G., Cimò S., Colella L., Fazzi D., Ortica F., Vurro V., Eleftheriou C.G., Shmal D., Maya-Vetencourt J.F., Bertarelli C., Lanzani G. and Benfenati F. Neuronal firing modulation by a membrane-targeted photoswitch. Nat Nanotechnol. 2020; DOI: 10.1038/s41565-019-0632-6             

-Lodola F.#, Rosti V., Tullii G., Desii A., Tapella L., Catarsi P., Lim D., Moccia F. and Antognazza M.R. Conjugated polymers optically regulate the fate of Endothelial Colony Forming Cells. Sci Adv. 27 Sep 2019: Vol. 5, no. 9, eaav4620. DOI: 10.1126/sciadv.aav4620.

-Lodola F.#, Vurro V., Crasto S., Di Pasquale E. and Lanzani G. Optical Pacing of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Mediated by a Conjugated Polymer Interface. Adv Healthcare Mater. 2019 May 8:e1900198. doi: 10.1002/adhm.201900198.                     

-Denegri M., Bongianino R., Lodola F.*, Boncompagni S., De Giusti V.C., Avelino-Cruz J.E., Liu N., Persampieri S., Curcio A., Esposito F., Pietrangelo L., Marty I., Villani L., Moyaho A., Baiardi P., Auricchio A., Protasi F., Napolitano C. and Priori S.G. A single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by Catecholaminergic Polymorphic Ventricular Tachycardia is able to cure the disease from birth to advanced age. Circulation. Jun 24;129(25):2673-81. DOI: 10.1161/CIRCULATIONAHA.113.006901

Lodola’s Lab – #LodolaLab_BtBs
last update: October 2020