Natalello Antonino, PhD
The activity is focused on the following research lines
Aging Diseases, Neurodegenerative and neurological diseases
Molecular modeling and Structural Biology
Amyloids, Bioanalytical Methods, Biophysics, FTIR Micro-spectroscopy, FTIR spectroscopy, Intact-cell Spectroscopy, Lipids, Protein Aggregation, Protein Stability, Spectroscopy.
-Protein folding, misfolding and aggregation in vitro and in situ studied by biophysical approaches, including infrared spectroscopy and micro-spectroscopy, optical spectroscopies (absorption, florescence, circular dichroism), and mass spectrometry. Major research topics: 1) protein stability; 2) amyloid aggregation; 3) structure-function relation; 4) aggregation of recombinant proteins; 5) protein-protein and protein-ligand interactions; 6) nano- and bio-materials.
-Bioanalytical applications of spectroscopic methods. Major research topics: FTIR (micro)spectroscopy of complex biological systems; in situ studies of biological processes; spectroscopic markers of neurodegenerative disorders in biofluids.
RITESSERE: Silk sericin materials from textile industry by-products (Progetto Cariplo)
-Sala BM, Le Marchand T, Pintacuda G, Camilloni C, Natalello A, Ricagno S. Conformational Stability and Dynamics in Crystals Recapitulate Protein Behavior in Solution. Biophys J. 2020; 119(5):978-988. doi: 10.1016/j.bpj.2020.07.015.
-Ami D, Mereghetti P, Foli A, Tasaki M, Milani P, Nuvolone M, Palladini G, Merlini G, Lavatelli F, Natalello A. ATR-FTIR Spectroscopy Supported by Multivariate Analysis for the Characterization of Adipose Tissue Aspirates from Patients Affected by Systemic Amyloidosis. Anal Chem. 2019; 91(4):2894-2900. doi: 10.1021/acs.analchem.8b05008.
-Ami D, Lavatelli F, Rognoni P, Palladini G, Raimondi S, Giorgetti S, Monti L, Doglia SM, Natalello A, Merlini G. In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study. Sci Rep. 2016; 6:29096. doi: 10.1038/srep29096.
-Natalello A, Mangione PP, Giorgetti S, Porcari R, Marchese L, Zorzoli I, Relini A, Ami D, Faravelli G, Valli M, Stoppini M, Doglia SM, Bellotti V, Raimondi S. Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS. J Biol Chem. 2016;291(18):9678-89. doi: 10.1074/jbc.M116.720573.
Natalello’s Lab – #NatalelloLab_BtBs
last update: May 2021