Strati Francesco, PhD

The activity is focused on the following research lines
Health research area BtBs UNIMIB
Health

Cancer, Inflammation and infections

Keywords

Gut microbiome; mucosal immunology; metagenomics

Research interest

My areas of interest focus on host-microbe interactions and the molecular mechanisms underlying the evolution and adaptation of the human gut microbiota in health and disease. My aim is to use an interdisciplinary approach exploiting all the meta'omics, immunology, in vivo models and computational biology in order to reduce the lack of knowledge concerning host-microbe interactions and crosstalk with the immune system. These new insights will lay the basis for the development of next-generation biotherapeutic approaches to address currently unmet medical needs.

At present, I am dissecting the role of the gut microbiota in shaping immune cell functions by using in-vivo models and ex-vivo specimens from patients to answer the long-lasting question regarding the environmental clues modulating the mucosal immune system.

Our research demonstrated that the gut microbiome is important to modulate the functionality of iNKT cells, lipid-reactive CD1d-restricted unconventional T cells, affecting the disease outcome in models of experimental colitis. We showed the IL10-mediated immunoregulatory role of mucosal iNKT cells in controlling pro-inflammatory T-helper cells to maintain intestinal immune homeostasis. Finally, we are describing the pathogenic potential of iNKT cells in the context of CRC.

Selected articles

-Burrello, C.*, Strati, F.*, Lattanzi, G., Diaz-Basabe, A., Mileti, E., Giuffrè, M. R., ... & Facciotti, F. (2022). IL10 secretion endows intestinal human iNKT cells with regulatory functions towards pathogenic T lymphocytes. Journal of Crohn's and Colitis. *contributed equally. DOI: 10.1093/ecco-jcc/jjac049

-Strati, F.*, Pujolassos, M., Burrello, C., Giuffrè, M. R., Lattanzi, G., Caprioli, F., ... & Facciotti, F. (2021). Antibiotic-associated dysbiosis affects the ability of the gut microbiota to control intestinal inflammation upon fecal microbiota transplantation in experimental colitis models. Microbiome, 9(1), 1-15. *Co-corresponding author. PMCID: PMC7868014, DOI: 10.1186/s40168-020-00991-x

-Strati, F., Cavalieri, D., Albanese, D., De Felice, C., Donati, C., Hayek, J., ... & De Filippo, C. (2017). New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome, 5(1), 1-11. PMCID: PMC5320696 , DOI: 10.1186/s40168-017-0242-1

International and national collaborations

Prof. Giandomenica Iezzi, Department of Surgery, Ente Ospedaliero Cantonale (EOC), Università Svizzera italiana (USI)

Prof. Antonio Calabrò, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, Università degli Studi di Firenze

Prof. Flavio Caprioli, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti dell’Università degli Studi di Milano

Prof. Yvan Torrente, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano


Strati’s Lab – #StratiLab_BtBs
last update: May
2022