Guglielmetti Simone Domenico

Full Professor in Agricultural Microbiology

Simone Domenico Guglielmetti BtBs UNIMIB

room 4068, building U4-Tellus, tel. +39 02 6448 3343

lab 4052, building U4-Tellus, tel. +39 02 6448 3371

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The activity is focused on the following research lines

FOOD BtBs UNIMIB research area

Novel and Functional Food, Nutraceutic

Enviromental Biodiversity and Ecosystem Reasearch area BtBs UNIMIB

Enviromental Biodiversity and Ecosystem

Microbial Diversity and Bioprospecting


Probiotics, Gut microbiome, Lactic acid bacteria, Bifidobacteria, Food-associated microorganisms, Human microbial ecosystems

Research Focus

SG's scientific endeavors center on applied microbiology and microbial biotechnology, with a primary emphasis on food, probiotics, and host-associated microorganisms. The overarching goal is to deepen our understanding of microbe-host interactions, contribute to the development of functional foods, and advance biotechnological strategies relevant to the food industry. Key research interests encompass microbial genetics, immunomodulation, microbial adhesion, metataxonomics, metabolomics, and the functional implementation of microbial strains.

Research Topics

Microbe-Host Interactions

Investigation of the interaction dynamics between food, probiotic, and host-associated bacterial strains and their impact on human hosts and animal models.
Exploration of the immunomodulatory properties of bifidobacteria and lactic acid bacteria, with a focus on identifying specific cell components influencing the host's immune system.
Characterization of bacterial adhesion to host epithelia, with a keen interest in delineating molecular determinants within bifidobacteria and lactic acid bacteria.

Microbial Ecosystems Analysis

Utilization of metataxonomics, metagenomics, and quantification of microbial metabolites to study microbial ecosystems associated with human hosts and animal models.
Investigation of the influence of dietary patterns and specific food components, particularly polyphenols, on the intestinal microbiome.
Examination of the effects of probiotic product oral intake on intestinal and vaginal microbiomes.
Characterization of intestinal microbiomes under specific physiological and metabolic conditions, particularly in relation to intestinal functional disorders and gut permeability.

Functional Characterization of Microorganism for Industry

Valorization of probiotic microbial strains for industrial applications in products with enhanced value.
Application of microorganisms for developing biotransformations and novel functional foods of industrial relevance.
Exploration of the persistence of probiotic strains in the human gastrointestinal tract when administered through commercially available food supplements (recovery trials).

Other Research Interests

Microbial Ecosystems in Food: Examination of microbial ecosystems associated with food.
Terminology and Quality Control: Contribution to the development of terminology and quality control practices within the realm of "biotic" products.

Research projects

Anno: 2023-2025
Bando: Programma Nazionale di Ricerca e Progetti di Rilevante Interesse Nazionale (PRIN) 2022  
Enti finanziatori: Ministero dell’Università e della Ricerca (MUR)

- MaPLE - Gut and blood microbiomics for studying the effect of a polyphenol-rich dietary pattern on intestinal permeability in the elderly
Anno: 2016-2019
Bando: Joint Action Intestinal Microbiomics della Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL)
Enti finanziatori: Ministero delle Politiche Agricole, Alimentari e Forestali (MIPAF)

Selected articles

*Guglielmetti S, Taverniti V, Minuzzo M, Arioli S, Stuknyte M, Karp M, Mora D. Oral bacteria as potential probiotics for the pharyngeal mucosa. Appl Environ Microbiol. 2010 Jun;76(12):3948-58.

*Guglielmetti S, Zanoni I, Balzaretti S, Miriani M, Taverniti V, De Noni I, Presti I, Stuknyte M, Scarafoni A, Arioli S, Iametti S, Bonomi F, Mora D, Karp M, Granucci F. Murein lytic enzyme TgaA of Bifidobacterium bifidum MIMBb75 modulates dendritic cell maturation through its cysteine- and histidine-dependent amidohydrolase/peptidase (CHAP) amidase domain. Appl Environ Microbiol. 2014 Sep;80(17):5170-7.

Aguilar-Toalá JE, Arioli S, Behare P, Belzer C, Berni Canani R, Chatel JM, D'Auria E, de Freitas MQ, Elinav E, Esmerino EA, García HS, da Cruz AG, González-Córdova AF, *GUGLIELMETTI S, de Toledo Guimarães J, Hernández-Mendoza A, Langella P, Liceaga AM, Magnani M, Martin R, Mohamad Lal MT, Mora D, Moradi M, *Morelli L, Mosca F, Nazzaro F, Pimentel TC, Ran C, Ranadheera CS, *Rescigno M, Salas A, Sant'Ana AS, Sivieri K, Sokol H, *Taverniti V, Vallejo-Cordoba B, Zelenka J, Zhou Z. Postbiotics - when simplification fails to clarify. Nat Rev Gastroenterol Hepatol. 2021 Nov;18(11):825-826.

Gargari G, Mantegazza G, Taverniti V, Gardana C, Valenza A, Rossignoli F, Barbaro MR, Marasco G, Cremon C, Barbara G, *GUGLIELMETTI S. Fecal short-chain fatty acids in non-constipated irritable bowel syndrome: a potential clinically relevant stratification factor based on catabotyping analysis. Gut Microbes. 2023 Dec;15(2):2274128.

Guglielmetti's Lab – #GuglielmettiLab_BtBs
Department of Biotechnology and Biosciences (BtBs) - University of Milano-Bicocca, Milan, Italy
last update: November 2023