Dipartimento di Biotecnologie e Bioscienze BtBs

Sessione Poster BtBsDay2020 - mattino

Giornata del Dipartimento di Biotecnologie e Bioscienze 2020

Sessione Poster dalle 11:45 alle 12:45

BtBsDay 2020 UNIMIB #BtBsDay
La sessione è RISERVATA ai frequentatori del Dipartimento di Biotecnologie e Bioscienze – UNIMIB

La richiesta di partecipazione alla sezione posters, per il personale esterno al dipartimento, sarà fatta via email direttamente al presentatore del poster al quale si e interessato.

Programma BtBsDay 2020
Sessione Poster - pomeriggio

P01 - Identification of spectroscopic markers of amyotrophic lateral sclerosis

P01_Ami Diletta_POSTER BtBsDay 2020

Ami D.1, Ambrosio F.1, Natalello A.1
E-mail: diletta.ami@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Amyotrophic lateral sclerosis, FTIR microspectroscopy, multivariate analysis, protein aggregation, protein misfolding, tears

P02 - Roasting process does not affect anti-inflammatory properties of coffee extracts

P02_Artusa Valentina_POSTER BtBsDay 2020

Artusa V.1, Ciaramelli C.1, Palmioli A.1, Airoldi C.1, Peri F.1
E-mail: v.artusa@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: coffee extract, phytochemicals, roasting, inflammation, cytokines

P03 - Dissecting the role of serine in neurological disorders

P03_Badone Beatrice_POSTER BtBsDay 2020

Badone B.1, Tripodi F.1, Coccetti P.1
E-mail: beatrice.badone@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Alzheimer’s Disease, hiPSC-astrocytes, neural stem cells, brain tissues, metabolism

P04 - Biofabrication of a vascularized 3D tissue in vitro model

P04_Barbugian Federica_POSTER BtBsDay 2020

Barbugian F.1,2, Bodet T. 2, Moroni L.2, Russo L.1, Nicotra F.1
E-mail: f.barbugian@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Institute for Technology-Inspired regenerative Medicine (MERLN), Netherlands
Keywords: Regenerative medicine, Tissue Engineering, Biofabrication, Breast cancer, Vasculogenesis, Bioprinting, Additive Manufacturing, hydrogel

P05 - Enzymatic hydrolysis of Camelina sativa meal for carotenoids production by the yeast Rhodosporidium toruloides

P05_Bertacchi Stefano_POSTER BtBsDay 2020

Bertacchi S.1, Cantù C.1, Branduardi P.1
E-mail: s.bertacchi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Bio-based products, Renewable resources, Biorefinery, Camelina meal, Enzymatic hydrolysis, Rhodosporidium toruloides, Carotenoids

P06 - Charge patterning and phase separation propensity in IDPs: is there a possible interplay?

P06_Bianchi Greta_POSTER BtBsDay 2020

Bianchi G.1, Dell’Orto L.2, Longhi S.2, Brocca S.1
E-mail: g.bianchi31@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2CNRS and Aix-Marseille University, Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Marseille, France
Keywords: protein conformation, protein coacervation, distribution of electrostatic charges

P07 - Analysis of cadmium effect on neural cells energetic metabolism using Seahorse technology

P07_Bovio Federica_POSTER BtBsDay 2020

Bovio F.1, Forcella M.1, Urani C.2, Fusi P.1
E-mail: f.bovio@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Earth and Environmental Sciences, University of Milan Bicocca, Milan, Italy
Keywords: cadmium, Seahorse, neural cells, energetic metabolism, glycolysis

P08 - Study of extracellular matrix glycosignature in dictate cell fate using 3D glyco-conjugate biomaterials

P08_Cadamuro Francesca_POSTER BtBsDay

Cadamuro F.1, Chiodo F.2, Nicotra F.1, Russo L.1
E-mail: f.cadamuro@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
Keywords: Glycans, Biomaterials, Extracellular matrix

P09 - Three-dimensional models for the study of breast cancer metabolism

P09_Campioni Gloria e Pasquale Valentina_POSTER BtBsDay 2020

Pasquale V.1,2*, Campioni G.1,2*, Ducci G.1,2, Savore A.1,2, Sacco E.1,2, Vanoni M.1,3
E-mail: valentina.pasquale@unimib.it, g.campioni@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
1SYSBIO, Centre of Systems Biology, Milan, Italy
* VP and GC equally contributed to this manuscript
Keywords: three-dimensional models, spheroids, organoids, breast cancer, metabolism

P10 - Dual role of Dpb4 in the DNA damage response

reserved

Casari E.1, Gobbini E.1, Calabrese S.1, Clerici M.1, Longhese MP.1
E-mail: e.casari@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: DSB, checkpoint, resection, chromatin, S. cerevisiae

Abstract not available

P11 - NMR-based dissection of cocoa anti-amyloidogenic activity

P11_Ciaramelli Carlotta_POSTER BtBsDay 2020

Ciaramelli C.1,4, Palmioli A.1,4, De Luigi A.2, Colombo L.2, Sala G.3,4, Salmona M.2, Airoldi C.1,4
E-mail: carlotta.ciaramelli@unimib.it
1 BioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2 Department of Molecular Biochemistry and Pharmacology, IRCCS- Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
3 School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
4 Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Milan, Italy
Keywords: Cocoa, flavanols, NMR, anti-amyloidogenic, Aβ peptides, Alzheimer’s disease

P12 - Developmental effects of β2V287L nAChR subunit on pyramidal neuron morphology in the neocortex

P12_Colombo Giulia_POSTER BtBsDay 2020

Colombo G.1, Modena D.2, Coatti A.1*, Amadeo A.2, Becchetti A.1
E-mail: g.colombo83@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2University of Milano, Milan, Italy
* Past affiliation
Keywords: epilepsy, sleep, nAChR, pyramidal neuron, cortex, dendrites, dendritic spines, ADSHE

P13 - Effects of Prebiotics and Probiotics on Human Gut Microbiota and Related Immune System: A Study on Healthy and Elderly Subjects

P13_De Giani Alessandra_POSTER BtBsDay 2020

De Giani A.1, Sandionigi A.1, Zampolli J.1, Michelotti A.2, Tursi F.2, Labra M.1, Di Gennaro P.1
E-mail: alessandra.degiani@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2CompLife Italia, Safety and Efficacy Lab, Italy
Keywords: Clinical study, Synbiotic, Prebiotics, Probiotics, Gut Microbiota

P14 - Cardoon roots valorization by combined microbial biotransformation for lactic acid production

P14_Di Lorenzo Raffaella Desirè_POSTER BtBsDay 2020

Di Lorenzo RD.1, Branduardi P.1
E-mail: raffaella.dilorenzo@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Cardoon, Inulin, Lactic acid, Synthetic consortium

P15 - High-resolution imaging and high-content analysis of mitochondrial efficiency and OXPHOS relevance in grade II bladder cancer cells

P15_Ducci Giacomo_POSTER BtBsDay 2020

Ducci G.1,2, Pasquale V.1,2, Campioni G.1,2, Ventrici A.1, Arrigoni E.1, Vanoni M.1,2, Vago R.3, Sacco E.1,2
E-mail: g.ducci@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO/ISBE.IT, Centre of Systems Biology, Milan, Italy
3Urological Research Institute, Division of Experimental Oncology, IRCCS San Raffaele Hospital, Milan, Italy
Keywords: bladder cancer, energy and redox metabolism, cellular bioenergetics, mitochondrial function, oxidative stress, operetta

P16 - Mechanism of action of new synthetic Toll-Like receptor 4 agonists for the development of innovative vaccine adjuvants

P16_Gotri Nicole_POSTER BtBsDay 2020

Gotri N.1, Facchini F.A.1, Romerio A.1, Luraghi A.1, Peri F.1
E-mail: n.gotri@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: TLR4, synthetic molecules, vaccine adjuvants, immunostimulators

Sessione Poster BtBsDay2020 - pomeriggio

Giornata del Dipartimento di Biotecnologie e Bioscienze 2020

Sessione Poster dalle 13:45 alle 14:45

BtBsDay 2020 UNIMIB #BtBsDay
La sessione è RISERVATA ai frequentatori del Dipartimento di Biotecnologie e Bioscienze – UNIMIB

La richiesta di partecipazione alla sezione posters, per il personale esterno al dipartimento, sarà fatta via email direttamente al presentatore del poster al quale si e interessato.

Programma BtBsDay
Sessione Poster - mattino

P17 - Glucosinolates as nutraceuticals: Process optimization and scale-up of Bio-based microbial production of glucobrassicin

P17_Maestroni Letizia_POSTER BtBsDay 2020

Maestroni L.1, Butti P.1, Branduardi P.1
E-mail: l.maestronj@campus.unimib.it
1IndBiotech lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: glucosinolates, circular economy, process design, yeasts, synthetic biology, golden gate assembly, CRISPR-Cas9, enzymes scaffolding

P18 - Engineered hybrid hydrogels as 3D bioprintable platform for preclinical investigations

P18_Magli Sofia_POSTER BtBsDay 2020

Magli S.1, Crippa L.2, Ballarini E.2, Smith A.2, Cavaletti G.2, Magni F.2, Bertini S.3, Cosentino C.3, Nicotra F.1, Russo L.1
E-mail: s.magli1@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2School of Medicine and Surgery, University of Milano-Bicocca, Vedado al Lambro (MB), Italy
3Institute for Chemical and Biochemical Research G. Ronzoni, Milan, Italy
Keywords: Hybrid Hydrogel, Click Chemistry, Diels Alder, 3D model, Bioprinting

P19 - Development of a sustainable bioprocess for the production of Vitamin B9

P19_Mastella_POSTER BtBsDay 2020

Mastella L.1, Bertacchi S.1, Senatore VG.1, Labra M.1, Beltrani T.2, Branduardi P.1
E-mail: l.mastella@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Laboratory for Resources Valorization (RISE), Department for Sustainability, ENEA- Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Italy
Keywords: Saccharomyces cerevisiae, Scheffersomyces stipitis, folate, metabolic engineering, residual biomasses, industrial symbiosis

P20 - Protein metabolite interaction and metabolic flux sensing are involved in glucose control of Snf1/AMPK activity

P20_Milanesi Riccardo_POSTER BtBsDay 2020

Milanesi R.1, Tripodi F.1, Coccetti P.1
E-mail: r.milanesi2@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Snf1/AMPK, Ras/PKA, glucose metabolism, protein metabolite interaction, signal transduction, flux sensing

P21 - Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse embryonic fibroblasts

P21_Oldani Monica_POSTER BtBsDay 2020

Oldani M.1, Manzoni M.2, Villa A.M.1, Stefanini F.M.3, Melchioretto P.4, Monti E.2, Forcella M.1 ,Urani C.4,5, Fusi P.1,5
E-mail: m.oldani12@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Molecular and Translational Medicine (DMTM), University of Brescia, Brescia, Italy
3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy
4Department of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, Italy
5Integrated Models for Prevention and Protection in Environmental and Occupational Health, (MISTRAL), Interuniversity Research Center, Italy
Keywords: Cadmium Carcinogenesis, Cell metabolism, DNA damage Mitochondria, Reactive oxygen species

P22 - A Sox2-Fos-Socs3 gene regulatory network controls the self-renewal of Neural Stem Cells

P22_Pagin Miriam_POSTER BtBsDay 2020

Pagin M.1, Giubbolini S.1, Pernebrink M.2,5, Sambruni G.1,3, Barone C.1, Pitasi M.1, Mercurio S.1, Ottolenghi S.1, Pavesi G.3, Wei CL.4, Cantù C.2,5, Nicolis SK.1
E-mail: m.pagin1@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2WCMM and Department of Biomedical and Clinical Sciences, Linköping University, Sweden
3Department of Biosciences, University of Milano, Italy
4The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
5Department of Biomedical and Clinical Sciences, Linköping University, Sweden
Keywords: Sox2, transcription factor, neural stem cells, self-renewal, long-range interactions, Socs3, Fos, rescue

P23 - Development of ultrasound assisted solid liquid extraction method for the recovery of bioactive compounds from cocoa shell by-product as natural source of functional ingredient

P23_Pagliari Stefania_POSTER BtBsDay 2020

Pagliari S.1, Rastrelli L. 2, Campone L.1
E-mail: stefania.pagliari@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Pharmacy, University of Salerno, Fisciano (SA), Italy
Keywords: Theobroma cacao, SALLE, chemometric analysis, Methylxanthines, UHPLC-HRMS-UV

P24 - Healthy compounds from vegetable matrices: an overview ranging from biodiversity to by-products

P24_Panzeri Davide_POSTER BtBsDay 2020

Panzeri D.1, Pagliari S.1, Giustra CM.1, Magoni C.1, Guzzetti L.1, Sacco G.1, Bruni I.1, Forcella M.1, Fusi P.1, Labra M.1
E-mail: davide.panzeri@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: bioprospecting, sustainability, bioactivity, by-products, biodiversity

P25 - The rediscovery of trehalose production by Saccharomyces cerevisiae

P25_Pessina Alex_POSTER BtBsDay 2020

Pessina A.1, Vanoni M.1,2, Brambilla L.1,2
E-mail: a.pessina9@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO – Centre of Systems Biology, Milan, Italy
Keywords: Trehalose, S. cerevisiae, Glutamic acid, fed-batch, Metabolic engineering

P26 - Living in the metropolis: how landscape anthropization shapes morphology of two charismatic insect pollinators

P26_Pioltelli Emiliano_POSTER BtBsDay 2020

Pioltelli E.1, Biella P.1, Tommasi N.1, Galimberti A.1 Labra M.1
E-mail: e.pioltelli@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Pollination, Urbanization, Landscape, Ecology, Morphology

P27 - Role of DNA damage response in R-Loops recognition and signalling

reserved

Pizzul P.1, Bonetti D.1
E-mail: p.pizzul@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: DNA damage, R-Loops, RNA-DNA Hybrids, Saccharomyces cerevisiae

Abstract not available

P28 - Evaluation of the prebiotic effects of new natural extracts on beneficial bacteria associated with human health

P28_Racca Tiziana_POSTER BtBsDay 2020

Racca T.1, De Giani A.1, Di Gennaro P.1
E-mail: tiziana.racca@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Prebiotics, Probiotics, Natural extracts, Health

P29 - Multimodal enhanced in vivo imaging of pancreatic β-cells using PGA-chitosan based nanoparticles

P29_Rossi Lorenzo_POSTER BtBsDay 2020

Rossi L.1, Russo L.1, Pignatelli C.1, Kerekes K.2, Körhegyi Z.2, Bodnar M.2, Kocsi J.2, Lindheimer F.3, Lindner M.3, Lindner S.3, Bartenstein P.3, Ziegler S.3, Nicotra F.1
E-mail: l.rossi58@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2BBS Nanotechnology, Debrecen, Hungary
3Department of Nuclear Medicine, Faculty of Medicine, University Hospital LMU, Munich, Germany
Keywords: in vivo targeting, multimodality, nanoparticles, pancreas, click chemistry

P30 - Development of vault-based nanovectors in Pichia pastoris and antibody-mediated targeting investigation on cancer cell lines

P30_Tomaino Giulia_POSTER BtBsDay 2020

Tomaino G.1, Pozzi M.1, Mazzucchelli M.1, Agresta A.1, Vanoni M.1,2, Frascotti G.1, Tortora P.1
E-mail: g.tomaino3@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO – Centre of Systems Biology, Italy
Keywords: Pichia pastoris, vault nanoparticle, cell targeting, breast cancer

P31 - DALIS in aging, inflammation and neurodegeneration

P31_Torinesi Roberta_POSTER BtBsDay 2020

Torinesi RS.1, Gatti E.2, Grandori R.1, Vai M.1, Orlandi I.1
E-mail: r.torinesi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Centre d’Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Marseille, France
Keywords: DALIS, dendritic cell, protein aggregate, Saccharomyces cerevisiae

P32 - Identification of novel gene asset of Rhodococcus opacus R7 for polyethylene degradation by RNA-seq approach

P32_Zampolli Jessica_POSTER BtBsDay 2020

Zampolli J.1, Orro A.2, Milanesi L.2, Di Gennaro P.1
E-mail: jessica.zampolli@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Institute of Biomedical Technologies, National Research Council, CNR, ITB-CNR, Italy
Keywords: Rhodococcus genus, RNA-seq analysis, biodegradation, plastic, polyethylene

P33 - Synthesis Optimization and Biological Characterization of New Toll-Like Receptor 4 (TLR4) Modulators

P33_Romerio Alessio_POSTER BtBsDay 2020

Alessio Romerio1, Andrea Luraghi1, Nicolé Gotri1, Valentina Artusa1, Simona D’amato1, Francesco Peri1
E-mail: a.romerio1@campus.unimib.it
1 Università di Milano-Bicocca, Department of Biotechnology and Bioscience, Milano
Keywords: <i>TLR4, Innate immunity, Inflammation, Medicinal Chemistry, Organic Chemistry</i>

Graphical Abstract BtBsDay2020 - sessione due

BtBsDay 2020 UNIMIB #BtBsDay

Giornata del Dipartimento di Biotecnologie e Bioscienze 2020

Questi Graphical Abstract sono stati redatti da alcuni studenti di laurea magistrale in tesi nel nostro dipartimento. Si tratta del progetto e dei risultati del loro lavoro di tesi, esposti in maniera tale da comunicarli a un pubblico più ampio di quello strettamente scientifico. Questi Graphical Abstract fanno parte dell'iniziativa "My Thesis in Bicocca" (#myTHESISinBICOCCA).

Programma BtBsDay 2020
GRAPHICAL ABSTRACT - sessione uno

GA11 - Ipotesi di meccanismo di soppressione tumorale mediata da overespressione ectopica di miRNA deregolati in glioma murino

Malighetti Federica_GRAPHICAL ABSTRACT BtBsDay 2020

PREMIO GRAPHICAL ABSTRACT BtBsDay2020

Federica Malighetti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Cristiana Barone

Gruppo di Ricerca: Prof.ssa Silvia Nicolis

GA12 - Effetto dello ione manganese sull’esterasi del batterio antartico Marinomonas ef1

Marchetti Alessandro_GRAPHICAL ABSTRACT BtBsDay 2020

Alessandro Marchetti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Marco Mangiagalli

Gruppo di Ricerca: Prof.ssa Marina Lotti

GA13 - Sintesi di nuovi potenziali antibatterici inibitori della formazione di biofilm per interazione multivalente

Marradi Lorenzo_GRAPHICAL ABSTRACT BtBsDay 2020

Lorenzo Marradi, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Lorenzo Rossi

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

GA14 - Approcci in vitro per lo sviluppo di biomateriali utili alla formulazione di modelli avanzati in 3D

Murenu Nicoletta_GRAPHICAL ABSTRACT BtBsDay 2020

Nicoletta Murenu, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Sofia Magli

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

GA15 - Ruolo di Sox2 e suoi target nel mantenimento e differenziamento delle cellule staminali neurali in vitro

Pitasi Mattia_GRAPHICAL ABSTRACT BtBsDay 2020

Mattia Pitasi, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Miriam Pagin

Gruppo di Ricerca: Prof.ssa Silvia Nicolis

GA16 - Integrazione di dati di trascrittomica e metabolomica per l’investigazione dell’eterogeneità metabolica in cellule di cancro al seno

Schiesaro Giovanni_GRAPHICAL ABSTRACT BtBsDay 2020

Giovanni Schiesaro, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

Gruppo di Ricerca: Dr.ssa Chiara Damiani

GA17 - Produzione di vitamina B9 da biomasse locali di scarto

Senatore Vittorio_GRAPHICAL ABSTRACT BtBsDay 2020

Vittorio G. Senatore, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Luca Mastella

Gruppo di Ricerca: Prof.ssa Paola Branduardi

GA18 - L’espressione della subunità mutante β2-V287L del recettore nicotinico eteromerico riduce il rilascio di glutammato sugli interneuroni fast-spiking del V strato della corteccia prefrontale

Simonti Martina_GRAPHICAL ABSTRACT BtBsDay 2020

Martina Simonti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Simone Meneghini

Gruppo di Ricerca: Prof. Andrea Becchetti

GA19 - Sintesi in fase solida di biopolimeri per un modello 3D di ECM intestinale

Valotti Ilaria_GRAPHICAL ABSTRACT BtBsDay 2020

Ilaria Valotti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Francesca Cadamuro

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

GA20 - Ruolo delle HSP nella risposta al danno al DNA

Zamprogno Marzia_GRAPHICAL ABSTRACT BtBsDay 2020

Marzia Zamprogno, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

Laboratorio di Biologia Molecolare Animale: Prof.ssa Silvia Barabino

Abstracts BtBsDay2020

BtBsDay 2020

Identification of spectroscopic markers of amyotrophic lateral sclerosis

BtBsDay UNIMIB

Ami D.1, Ambrosio F.1, Natalello A.1
E-mail: diletta.ami@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Amyotrophic lateral sclerosis, FTIR microspectroscopy, multivariate analysis, protein aggregation, protein misfolding, tears

Effects of HSP proteins on FUS aggregates modulation

BtBsDay UNIMIB

Arlati F.1, Zamprogno M.1, Levone BR.1, Barabino SML.1
E-mail: f.arlati7@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: FUS, protein aggregation, chaperones, HSP, DNA damage, ALS

Roasting process does not affect anti-inflammatory properties of coffee extracts

BtBsDay UNIMIB

Artusa V.1, Ciaramelli C.1, Palmioli A.1, Airoldi C.1, Peri F.1
E-mail: v.artusa@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: coffee extract, phytochemicals, roasting, inflammation, cytokines

Dissecting the role of serine in neurological disorders

BtBsDay UNIMIB

Badone B.1, Tripodi F.1, Coccetti P.1
E-mail: beatrice.badone@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Alzheimer’s Disease, hiPSC-astrocytes, neural stem cells, brain tissues, metabolism

Biofabrication of a vascularized 3D tissue in vitro model

BtBsDay UNIMIB

Barbugian F.1,2, Bodet T. 2, Moroni L.2, Russo L.1, Nicotra F.1
E-mail: f.barbugian@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Institute for Technology-Inspired regenerative Medicine (MERLN), Netherlands
Keywords: Regenerative medicine, Tissue Engineering, Biofabrication, Breast cancer, Vasculogenesis, Bioprinting, Additive Manufacturing, hydrogel

Enzymatic hydrolysis of Camelina sativa meal for carotenoids production by the yeast Rhodosporidium toruloides

BtBsDay UNIMIB

Bertacchi S.1, Cantù C.1, Branduardi P.1
E-mail: s.bertacchi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Bio-based products, Renewable resources, Biorefinery, Camelina meal, Enzymatic hydrolysis, Rhodosporidium toruloides, Carotenoids

Charge patterning and phase separation propensity in IDPs: is there a possible interplay?

BtBsDay UNIMIB

Bianchi G.1, Dell’Orto L.2, Longhi S.2, Brocca S.1
E-mail: g.bianchi31@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2CNRS and Aix-Marseille University, Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Marseille, France
Keywords: protein conformation, protein coacervation, distribution of electrostatic charges

Analysis of cadmium effect on neural cells energetic metabolism using Seahorse technology

BtBsDay UNIMIB

Bovio F.1, Forcella M.1, Urani C.2, Fusi P.1
E-mail: f.bovio@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Earth and Environmental Sciences, University of Milan Bicocca, Milan, Italy
Keywords: cadmium, Seahorse, neural cells, energetic metabolism, glycolysis

Glucobrassicin production in yeast using a synthetic biology approach

Butti P.1, Maestroni L.1, Branduardi P.1
E-mail: p.butti@campus.unimib.it
1IndBiotech lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: glucosinolates, yeasts, synthetic biology, golden gate assembly, CRISPR-Cas9, enzymes scaffolding

Study of extracellular matrix glycosignature in dictate cell fate using 3D glyco-conjugate biomaterials

Cadamuro F.1, Chiodo F.2, Nicotra F.1, Russo L.1
E-mail: f.cadamuro@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
Keywords: Glycans, Biomaterials, Extracellular matrix

Towards the valorisation of cinnamon bark extract residue: microbial fermentation for carotenoids production

Cantù C.1, Bertacchi S.1, Pagliari S.2, Bruni I.2, Labra M.2, Branduardi P.1
E-mail: c.cantu@campus.unimib.it
1IndBioTech Lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2ZooPlantLab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Cinnamon, Carotenoids, Rhodosporidium toruloides, Circular economy

Dual role of Dpb4 in the DNA damage response

Casari E.1, Gobbini E.1, Calabrese S.1, Clerici M.1, Longhese MP.1
E-mail: e.casari@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: DSB, checkpoint, resection, chromatin, S. cerevisiae

Abstract not available

Polymeric nanoparticles decorated for in vivo multimodal imaging

Cecchi S. 1, Rossi L.1, Nicotra F.1, Russo L.1
E-mail: s.cecchi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: polymeric nanoparticles, click chemistry, multimodal imaging, in vivo detection, β-cells

NMR-based dissection of cocoa anti-amyloidogenic activity

Ciaramelli C.1,4, Palmioli A.1,4, De Luigi A.2, Colombo L.2, Sala G.3,4, Salmona M.2, Airoldi C.1,4
E-mail: carlotta.ciaramelli@unimib.it
1 BioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2 Department of Molecular Biochemistry and Pharmacology, IRCCS- Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
3 School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
4 Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Milan, Italy
Keywords: Cocoa, flavanols, NMR, anti-amyloidogenic, Aβ peptides, Alzheimer’s disease

Developmental effects of β2V287L nAChR subunit on pyramidal neuron morphology in the neocortex

Colombo G.1, Modena D.2, Coatti A.1*, Amadeo A.2, Becchetti A.1
E-mail: g.colombo83@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2University of Milano, Milan, Italy
* Past affiliation
Keywords: epilepsy, sleep, nAChR, pyramidal neuron, cortex, dendrites, dendritic spines, ADSHE

A possible integrated model of hydroxycitric acid based on analyses in Saccharomyces cerevisiae

Croci G.1, Colombo S.1, Baroni MD.1,2, Martegani E.1
E-mail: g.croci4@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Biology, University of Padua, Padua, Italy
Keywords: Aging, Caloric restriction mimetics, Hydroxycitric acid, Autophagy

Synthesis and optimization of small molecules as modulators of Toll-like Receptor 4 (TLR4)

D’Amato S.1, Romerio A.1, Peri F.1
E-mail: s.damato@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Innate immunity, TLR4 agonists, vaccine adjuvants, lipopolysaccharide

Abstract not available

Effects of short chain alcohol on Candida antarctica Lipase B

De Divitiis M.1, Mangiagalli M.1, Natalello A.1, Lotti M.1
E-mail: m.dedivitiis1@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: N435, CALB, organic solvents

Effects of Prebiotics and Probiotics on Human Gut Microbiota and Related Immune System: A Study on Healthy and Elderly Subjects

De Giani A.1, Sandionigi A.1, Zampolli J.1, Michelotti A.2, Tursi F.2, Labra M.1, Di Gennaro P.1
E-mail: alessandra.degiani@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2CompLife Italia, Safety and Efficacy Lab, Italy
Keywords: Clinical study, Synbiotic, Prebiotics, Probiotics, Gut Microbiota

Cardoon roots valorization by combined microbial biotransformation for lactic acid production

Di Lorenzo RD.1, Branduardi P.1
E-mail: raffaella.dilorenzo@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Cardoon, Inulin, Lactic acid, Synthetic consortium

High-resolution imaging and high-content analysis of mitochondrial efficiency and OXPHOS relevance in grade II bladder cancer cells

Ducci G.1,2, Pasquale V.1,2, Campioni G.1,2, Ventrici A.1, Arrigoni E.1, Vanoni M.1,2, Vago R.3, Sacco E.1,2
E-mail: g.ducci@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO/ISBE.IT, Centre of Systems Biology, Milan, Italy
3Urological Research Institute, Division of Experimental Oncology, IRCCS San Raffaele Hospital, Milan, Italy
Keywords: bladder cancer, energy and redox metabolism, cellular bioenergetics, mitochondrial function, oxidative stress, operetta

Mechanism of action of new synthetic Toll-Like receptor 4 agonists for the development of innovative vaccine adjuvants

Gotri N.1, Facchini F.A.1, Romerio A.1, Luraghi A.1, Peri F.1
E-mail: n.gotri@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: TLR4, synthetic molecules, vaccine adjuvants, immunostimulators

Is “Post-Rest Potentiation” (PRP) a SERCA or NCX function index?

Leone J.1, Pane D.1, Ferè B.1, MS, Lodola F.1, Zaza A.1
E-mail: j.leone2@campus.unimib.it
1Laboratory of Cardiac Cellular Physiology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Post-rest potentiation, SERCA, NCX, calcium transient, drug testing

The cellular response to DNA damage induced by R-loops

Longaretti M.1, Bonetti D.1
E-mail: m.longaretti4@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: R-loops, DNA Damage, replication stress, DDR

Abstract not available

Detection of PKA activity in Saccharomyces cerevisiae cell population using Fluorescence Resonance Energy Transfer (FRET) probes

Longoni E.1, Colombo S.1, Martegani E.1
E-mail: e.longoni15@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Yeast, PKA, FRET, AKAR3, glucose

Glucosinolates as nutraceuticals: Process optimization and scale-up of Bio-based microbial production of glucobrassicin

Maestroni L.1, Butti P.1, Branduardi P.1
E-mail: l.maestronj@campus.unimib.it
1IndBiotech lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: glucosinolates, circular economy, process design, yeasts, synthetic biology, golden gate assembly, CRISPR-Cas9, enzymes scaffolding

Engineered hybrid hydrogels as 3D bioprintable platform for preclinical investigations

Magli S.1, Crippa L.2, Ballarini E.2, Smith A.2, Cavaletti G.2, Magni F.2, Bertini S.3, Cosentino C.3, Nicotra F.1, Russo L.1
E-mail: s.magli1@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2School of Medicine and Surgery, University of Milano-Bicocca, Vedado al Lambro (MB), Italy
3Institute for Chemical and Biochemical Research G. Ronzoni, Milan, Italy
Keywords: Hybrid Hydrogel, Click Chemistry, Diels Alder, 3D model, Bioprinting

Overexpression of miR-133c and miR-362-3p in mouse oligodendroglioma could be part of a tumor suppression mechanism

Malighetti F.1, Barone C.1, Nicolis SK.1
E-mail: f.malighetti@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: miRNA, SOX2, oligodendroglioma, cancer stem cells, mouse, tumor suppressor gene

Effects of manganese ion on Antarctic esterase

Marchetti A.1, Mangiagalli M.1, Lotti M.1
E-mail: a.marchetti20@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Extremozyme, psychrophiles, esterase, manganese, characterization, activity, structure

Synthesis of new potential inhibitors of biofilm formation for multivalent interaction

Marradi L.1, Rossi L.1, Russo L.1, Nicotra F.1, Titz A.2
E-mail: l.marradi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Saarbrucken, Germany
Keywords: P. Aeruginosa, biofilm, glycomimetic, conjugation, inhibitors, bacterium resistance, lectinB, multivalency

Development of a sustainable bioprocess for the production of Vitamin B9

Mastella L.1, Bertacchi S.1, Senatore VG.1, Labra M.1, Beltrani T.2, Branduardi P.1
E-mail: l.mastella@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Laboratory for Resources Valorization (RISE), Department for Sustainability, ENEA- Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Italy
Keywords: Saccharomyces cerevisiae, Scheffersomyces stipitis, folate, metabolic engineering, residual biomasses, industrial symbiosis

Protein metabolite interaction and metabolic flux sensing are involved in glucose control of Snf1/AMPK activity

Milanesi R.1, Tripodi F.1, Coccetti P.1
E-mail: r.milanesi2@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Snf1/AMPK, Ras/PKA, glucose metabolism, protein metabolite interaction, signal transduction, flux sensing

3D in vitro advanced models based on bioprintable engineered hydrogels

Murenu N.1, Magli S.1, Russo L.1, Nicotra F.1
E-mail: n.murenu@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: ECM, Biopolymers, Hybrid Hydrogels, Diels Alder reaction, Bioprinting, 3D models, Bioinks

Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse embryonic fibroblasts

Oldani M.1, Manzoni M.2, Villa A.M.1, Stefanini F.M.3, Melchioretto P.4, Monti E.2, Forcella M.1 ,Urani C.4,5, Fusi P.1,5
E-mail: m.oldani12@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Molecular and Translational Medicine (DMTM), University of Brescia, Brescia, Italy
3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy
4Department of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, Italy
5Integrated Models for Prevention and Protection in Environmental and Occupational Health, (MISTRAL), Interuniversity Research Center, Italy
Keywords: Cadmium Carcinogenesis, Cell metabolism, DNA damage Mitochondria, Reactive oxygen species

A Sox2-Fos-Socs3 gene regulatory network controls the self-renewal of Neural Stem Cells

Pagin M.1, Giubbolini S.1, Pernebrink M.2,5, Sambruni G.1,3, Barone C.1, Pitasi M.1, Mercurio S.1, Ottolenghi S.1, Pavesi G.3, Wei CL.4, Cantù C.2,5, Nicolis SK.1
E-mail: m.pagin1@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2WCMM and Department of Biomedical and Clinical Sciences, Linköping University, Sweden
3Department of Biosciences, University of Milano, Italy
4The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
5Department of Biomedical and Clinical Sciences, Linköping University, Sweden
Keywords: Sox2, transcription factor, neural stem cells, self-renewal, long-range interactions, Socs3, Fos, rescue

Development of ultrasound assisted solid liquid extraction method for the recovery of bioactive compounds from cocoa shell by-product as natural source of functional ingredient

Pagliari S.1, Rastrelli L. 2, Campone L.1
E-mail: stefania.pagliari@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Department of Pharmacy, University of Salerno, Fisciano (SA), Italy
Keywords: Theobroma cacao, SALLE, chemometric analysis, Methylxanthines, UHPLC-HRMS-UV

Healthy compounds from vegetable matrices: an overview ranging from biodiversity to by-products

Davide P.1, Pagliari S.1, Giustra CM.1, Magoni C.1, Guzzetti L.1, Sacco G.1, Bruni I.1, Forcella M.1, Fusi P.1, Labra M.1
E-mail: davide.panzeri@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: bioprospecting, sustainability, bioactivity, by-products, biodiversity

Three-dimensional models for the study of breast cancer metabolism

Pasquale V.1,2*, Campioni G.1,2*, Ducci G.1,2, Savore A.1,2, Sacco E.1,2, Vanoni M.1,3
E-mail: valentina.pasquale@unimib.it, g.campioni@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
1SYSBIO, Centre of Systems Biology, Milan, Italy
* VP and GC equally contributed to this manuscript
Keywords: three-dimensional models, spheroids, organoids, breast cancer, metabolism

The rediscovery of trehalose production by Saccharomyces cerevisiae

Pessina A.1, Vanoni M.1,2, Brambilla L.1,2
E-mail: a.pessina9@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO – Centre of Systems Biology, Milan, Italy
Keywords: Trehalose, S. cerevisiae, Glutamic acid, fed-batch, Metabolic engineering

Living in the metropolis: how landscape anthropization shapes morphology of two charismatic insect pollinators

Pioltelli E.1, Biella P.1, Tommasi N.1, Galimberti A.1 Labra M.1
E-mail: e.pioltelli@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Pollination, Urbanization, Landscape, Ecology, Morphology

Sox2 and its targets in Neural Stem Cells self-renewal and differentiation

Pitasi M.1, Pagin M.1, Nicolis SK.1
E-mail: m.pitasi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Sox2, Socs3, Fos, NSCs, transcription factor, self-renewal, differentiation, transduction

Role of DNA damage response in R-Loops recognition and signalling

Pizzul P.1, Bonetti D.1
E-mail: p.pizzul@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: DNA damage, R-Loops, RNA-DNA Hybrids, Saccharomyces cerevisiae

Abstract not available

Evaluation of the prebiotic effects of new natural extracts on beneficial bacteria associated with human health

Racca T.1, De Giani A.1, Di Gennaro P.1
E-mail: tiziana.racca@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Prebiotics, Probiotics, Natural extracts, Health

Multimodal enhanced in vivo imaging of pancreatic β-cells using PGA-chitosan based nanoparticles

Rossi L.1, Russo L.1, Pignatelli C.1, Kerekes K.2, Körhegyi Z.2, Bodnar M.2, Kocsi J.2, Lindheimer F.3, Lindner M.3, Lindner S.3, Bartenstein P.3, Ziegler S.3, Nicotra F.1
E-mail: l.rossi58@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2BBS Nanotechnology, Debrecen, Hungary
3Department of Nuclear Medicine, Faculty of Medicine, University Hospital LMU, Munich, Germany
Keywords: in vivo targeting, multimodality, nanoparticles, pancreas, click chemistry

Integration of transcriptomics and metabolomics data to investigate metabolic heterogeneity in breast cancer cells

Schiesaro G.3, Damiani C.1,2,3, Pescini P.1,2, Di Filippo M.2,3
E-mail: g.schiesaro@campus.unimib.it
1Department of Informatics, Systems and Communication, University of Milan-Bicocca, Milan, Italy
2SYSBIO Centre of Systems Biology, Milan, Italy
3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Flux Balance Analysis, Systems Biology, Metabolism, Cancer, Genome Scale Model, Data Integration

Production of vitamin B9 from local residual biomasses

Senatore VG.1, Mastella L.1, Branduardi P.1
E-mail: v.senatore@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Saccharomyces cerevisiae, Scheffersomyces stipitis, folate, metabolic engineering, residual biomasses, industrial symbiosis

β2-V287L nicotinic receptor subunit expression reduces glutamate release on fast-spiking neurons in layer V prefrontal cortex

Simonti M.1, Meneghini S.1, Becchetti A.1
E-mail: m.simonti@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: ADSHE, frontal lobe epilepsy, nicotinic receptor, glutamate release

Development of vault-based nanovectors in Pichia pastoris and antibody-mediated targeting investigation on cancer cell lines

Tomaino G.1, Pozzi M.1, Mazzucchelli M.1, Agresta A.1, Vanoni M.1,2, Frascotti G.1, Tortora P.1
E-mail: g.tomaino3@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2SYSBIO – Centre of Systems Biology, Italy
Keywords: Pichia pastoris, vault nanoparticle, cell targeting, breast cancer

DALIS in aging, inflammation and neurodegeneration

Torinesi RS.1, Gatti E.2, Grandori R.1, Vai M.1, Orlandi I.1
E-mail: r.torinesi@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Centre d’Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Marseille, France
Keywords: DALIS, dendritic cell, protein aggregate, Saccharomyces cerevisiae

Solid phase synthesis of biopolymers for 3D intestinal ECM model

Valotti I.1, Cadamuro F.1, Nicotra F.1, Russo L.1
E-mail: i.valotti@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Solid phase synthesis, Bio-inks, Biopolymers, 3D bioprinting, Collagen, Hyaluronic acid, Intestinal 3D model

Identification of novel gene asset of Rhodococcus opacus R7 for polyethylene degradation by RNA-seq approach

Zampolli J.1, Orro A.2, Milanesi L.2, Di Gennaro P.1
E-mail: jessica.zampolli@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2Institute of Biomedical Technologies, National Research Council, CNR, ITB-CNR, Italy
Keywords: Rhodococcus genus, RNA-seq analysis, biodegradation, plastic, polyethylene

Effects of HSP proteins in DNA damage response

Zamprogno M.1, Arlati F.1, Levone BR.1, Barabino SML.1
E-mail: m.zamprogno@campus.unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: FUS, HSP, DNA damage, ALS, ETO, RBP

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