Ronchi Antonella, PhD
Associate Professor of Genetics
room 3045, building U3, tel.: +39 02 6448 3337
lab 3021, building U3, tel.: +39 02 6448 3317
Molecular Genetics of Hematopoiesis Lab (Biomedicine area)
Research Group
Barbarani Gloria – PostDoc
lab 3021, building U3, tel. +39 02 6448 3317, gloria.barbarani@unimib.it
Agata Labedz – PhD student
lab 3021, building U3, tel. +39 02 6448 3317, agata.labedz@unimib.it
Stucchi Sarah – Master student
lab 3021, building U3, tel. +39 02 6448 3317, s.stucchi@campus.unimib.it
Keywords
cell differentiation , hematopoiesis, erythropoiesis, transcription factors, transcriptional regulation, hemoglobin switching
Research interests
Mechanisms controlling cell specification and differentiation in hematopoiesis.
Molecular control of erythropoiesis:
-mechanisms of Hereditary Persistence of Fetal Hemoglobin: research on globin gene activity and function (mRNA translation, inherited structural and regulatory defects, transcriptional control).
-transcriptional control of the expression of genes encoding erythroid transcription factors, in particular GATA 1 (and its transcriptional and post-transcriptional regulation), Sox6 and NR2F2.
-study of the transcriptional regulation of the “stem cell” gene c-Kit
-identification and functional analysis of genes differentially expressed during erythropoiesis
-signal transduction mechanisms controlling cell commitment and differentiation in normal and pathological (leukemias, myelodysplastic syndromes) erythropoiesis
-development of high-content high throughout assays to identify drugs reactivating fetal globins genes.
Research areas
Genetics and molecular biology of hematopoiesis
Research projects
-3DGenCa, 3D Genome architecture in Cancer
Anno: 2024
Bando: FAQC 2024 - seconda finestra
Enti finanziatori: Università degli Studi di MILANO-BICOCCA
-Understanding dyserythropoiesis to identify new therapeutic mechanisms in hereditary anemias
Anno: 2021
Bando: Decreto Direttoriale n.1628 del 16-10-2020 - Bando PRIN 2020
Enti finanziatori: M.I.U.R. - MINISTERO DELL'ISTRUZIONE, DELL'UNIVERSITA' E DELLA RICERCA - UFFICIO I - Bilancio e Contabilita'. Coordinamento staff della Direzione
-ARCH -AGE-RELATED CHANGES IN HEMATOPOIESIS
Anno: 2018
Bando: H2020- MSCA-ITN-2018
Enti finanziatori: EUROPEAN COMMISSION
Selected publications
Cristina Fugazza, Gloria Barbarani, Sudharshan Elangovan, Maria Giuseppina Marini, Serena Giolitto, Isaura Font-Monclus, Maria Franca Marongiu, Laura Manunza, John Strouboulis, Claudio Cantù, Fabio Gasparri, Barabino Silvia M.L., Yukio Nakamura, Sergio Ottolenghi, Paolo Moi and Antonella Ellena Ronchi “The Coup-TFII orphan nuclear receptor is an activator of the g-globin gene” Haematologica, accepted for publication.
Barbarani G, Fugazza C, Barabino SML, Ronchi AE. SOX6 blocks the proliferation of BCR-ABL1(+) and JAK2V617F(+) leukemic cells. Sci Rep. 2019; 9:3388. PMID: 30833651.
Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, Bosè F, Ottolenghi S, Ferrari G, Ronchi A. “Sox6 enhances erythroid differentiation in human erythroid progenitors” Blood 117:3669-79 (2011).
Cantu’ C., Grande V., Alborelli I., Cassinelli L., Cantù I., Colzani M.T., Ierardi R., Ronzoni L., Cappellini M.D., Ferrari G., Ottolenghi S., Ronchi A “A highly conserved Sox6 double binding site mediates Sox6 gene downregulation in erythroid cells” Nucleic Acids Research 39:486-501 (2011).
Ronchi’s Lab – #RonchiLab_BtBs
last update: April 2025