Comment by Sofia Magli ( #RussoLab_BtBs )
Bladder cancer is among the top ten most common cancer types in the world, with approximately 550,000 new cases annually. It has gained ground how the study of multifactorial diseases metabolism can lead to early diagnosis methods or increase effectiveness of therapeutic approaches. In this area, our PhD students Gloria Campioni ( #VanoniLab_BtBs ) and Giacomo Ducci ( #SaccoLab_BtBs ) contributed to the publication “Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties” published by the well-known MDPI journal Cells. The study focused on the invasive properties characterization of two Grade2 cancer tumor lines and then proceeded to analyze their metabolism and the use of nurients, in order to identify potential weaknesses of the cellular system that can be targeted with drug treatments. The obtained results suggest that oxidative phosphorylation could be the right target to counteract the invasiveness of Grade2 bladder cancer cells.
Check out the full open access article at this link: https://doi.org/10.3390/cells9122669