Seminario - Biotecnologie e Bioscienze - Mercoledì 22 ottobre 2025, ore 16:30, edificio BIOS-U3, aula U3-10
Balwant S. Tuana, Department of Cellular and Molecular Medicine, Director of the Graduate Program in Cellular and Molecular Medicine, Ottawa University, Canada.
Abstract
SLMAP belongs to the superfamily of tail anchored membrane proteins involved in diverse functions including vesicle transport, membrane fusion, ion channel regulation. SLMAP is a component of the MTOC, and subcellular membranes including the nuclear envelope and has been reported to be a negative regulator of Hippo signaling. SLMAP is also believed to integrate signaling through STRIPAK (kinase/PP2)-adaptor complex to guide growth and development. Using gain /loss of function models (mice, cells, organoids) data is revealing new mechanisms of SLMAP action in developing tissue. Mutations in SLMAP are being linked to rare disease and support its further interrogation as a therapeutic target.
Ospite: Francesco Lodola
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