BtBs seminar - Tail-anchored membrane protein SLMAP directs the MTOC and STRIPAK to guide growth and development

Balwant S. Tuana, Department of Cellular and Molecular Medicine, Director of the Graduate Program in Cellular and Molecular Medicine, Ottawa University, Canada.

SLMAP belongs to the superfamily of tail anchored membrane proteins involved in diverse functions including vesicle transport, membrane fusion, ion channel regulation.  SLMAP is a component of the MTOC, and subcellular membranes including the nuclear envelope and has been reported to be a negative regulator of Hippo signaling. SLMAP is also believed to integrate signaling through STRIPAK (kinase/PP2)-adaptor complex to guide growth and development. Using gain /loss of function models (mice, cells, organoids) data is revealing new mechanisms of SLMAP action in developing tissue. Mutations in SLMAP are being linked to rare disease and support its further interrogation as a therapeutic target.

Host: Francesco Lodola

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

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