BtBs seminario - Nanoscale Control of the Heartbeat - Biophysics Week 2025 Affiliate Event

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William Louch, University of Oslo, Norway. Giovedì 27 marzo 2025, ore 16:30, edificio BIOS-U3, aula U3-04 e Webex

Seminario - Biotecnologie e Bioscienze - Giovedì 27 marzo 2025, ore 16:30, edificio BIOS-U3, aula U3-04 e Webex

Biophysics Week 2025 Affiliate Event

 

William Louch, University of Oslo, Norway

Louch group

Abstract

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Seminari-BtBs-UNIMIB

Contraction of the heart is reliant on the shortening of individual cardiomyocytes, elicited by Ca2+ release at sub-cellular structures called dyads. However, the precise arrangement and function of dyads remains unclear, both in health and disease. Our work has examined this critical question using emerging microscopy techniques, including live-cell super-resolution (PALM) imaging. Our results show that nanoscale changes in dyadic structure promote fine-tuning of Ca2+ release in health, but deranged Ca2+ homeostasis during heart failure. These data suggest that newfound regulators of dyadic structure and function may serve as novel therapeutic targets in this disease.

Ospite: Antonio Zaza, Francesco Lodola

Il seminario sarà trasmesso anche in streaming su Webex:
https://unimib.webex.com/unimib-it/j.php?MTID=m361b4ee63abdc8da55337e9dcb010325

Password: day27

per informazioni:  infobtbs@unimib.it


cerca:   #BtBsSeminar  ,   #BtBsUNIMIB  ,  #BtBsSeminars

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