08 novembre 2022

Work in Progress seminar - PLN-R14del mutation: pathogenetic mechanism in a transgenic mouse model of dilated cardiomyopathy

Claudia Maniezzi, martedì 8 novembre, 2022, ore 16:30, edificio BIOS, aula 2025

WiP seminar, martedì 8 novembre, 2022, ore 16:30, edificio BIOS, aula 2025

Claudia Maniezzi, Department of Biotechnology and Biosciences, University of Milano-Bicocca

Zaza’s Lab

Abstract
Seminari-BtBs-UNIMIB

The sarco/endoplasmic Ca2+ ATPase 2a (SERCA2a) and its inhibitor phospholamban (PLN) play a key role in cardiac excitation-contraction coupling. The heterozygous human PLN-R14del mutation is associated with an arrhythmogenic dilated cardiomyopathy with clinical onset at middle age. We tried to shed light on the pathophysiology by evaluating intracellular Ca2+ dynamics and metabolism in ventricular cardiomyocytes isolated from heterozygous (Mut) mice and WT littermates in a presymptomatic stage. Further studies will clarify the interplay between alterations in Ca2+ dynamics and mitochondrial derangements in the PLN-R14 del pathogenesis.

Il seminario si svolgerà solo in presenza.

Gli attestati di partecipazione al seminario saranno emessi su richiesta e SOLO ai partecipanti che saranno presenti in aula e che avranno firmato il FOGLIO PRESENZE.

Gli attestati sono validi anche per l’acquisizione dei CFU, per altre informazioni e richiesta, visitare il link dedicato.

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