BtBs seminario - Protein Folding Pathways Across Physiology & Therapy

Emiliano Biasini, Università di Trento

Advanced computational methods have allowed us to define a novel drug discovery paradigm, called PPI-FIT, to suppress protein expression by acting on folding pathways. To translate such a conceptual framework to physiological contexts, we assessed the solvent accessibility of 87,138 modified residues in the human proteome and discovered that one-third of phosphorylated proteins have phosphosites buried within their core. These cryptic phosphosites likely become exposed during folding, influencing protein expression. Our findings re-define the intricate regulatory landscape of protein folding and open up possibilities for therapeutic interventions.

Ospite: Francesco Peri

Il seminario è APERTO a tutti.

per informazioni:  infobtbs@unimib.it

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