BtBs seminario - MOK, a new signalling kinase in microglia involved in neurodegenerative inflammation

Cintia Roodveldt, CABIMER-Center for Molecular Biology & Regenerative Medicine, University of Seville, Spain

Neuroinflammation is an early feature in Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases and microglial neurotoxic responses are considered to have a key role in disease onset and progression. However, the mechanisms underlying dysregulated microglial activation and inflammatory responses remain incompletely understood. We have recently revealed that MOK kinase plays a role in CNS immunity by controlling microglial responses that involve epigenetic mechanisms. Moreover, recent results uncover other MOK-supported signalling pathways. Importantly, based on our results from studies with a preclinical model, we propose that MOK has a role in the pathophysiology of ALS.

Ospite:  Daniela Ferrari

LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=maedc28c0e20c75458ae9aeecf469a48c

password:  day01 (32901 da telefoni e sistemi video)

Il seminario è APERTO a tutti.

tag:   #BtBsSeminars , #FerrariLab_BtBs