BtBs seminario - Genetic and acquired heterotopic ossification: a tale of bone and blood

Silvia Brunelli, School of Medicine and Surgery, University of Milano-Bicocca

Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital disorder causing abnormal bone growth in muscles due to a gene mutation (R206H) in Acvr1, activating bone morphogenetic proteins and activin A pathways. Inflammatory flare-ups trigger this process. Macrophages' role in affected tissues is unclear. Using mouse models, we simulated acquired and genetic HO, investigating the innate immune system's role in bone formation. Single-cell transcriptomics and imaging suggest early collaboration between macrophages and mesenchymal cells, fostering bone formation.

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tags:   #BtBsSeminar  ,  #BtBsUNIMIB  ,  #BtBsSeminars

per informazioni:  infobtbs@unimib.it