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Silvia Brunelli, School of Medicine and Surgery, UNIMIB - Thursday 23 May 2024, 4.30pm, U4-TELLUS building, room U4-01
Seminar - Biotechnology and Biosciences - Thursday 23 May 2024, 4.30 pm, U4-TELLUS building, room U4-01
Silvia Brunelli, School of Medicine and Surgery, University of Milano-Bicocca
Abstract
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Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital disorder causing abnormal bone growth in muscles due to a gene mutation (R206H) in Acvr1, activating bone morphogenetic proteins and activin A pathways. Inflammatory flare-ups trigger this process. Macrophages' role in affected tissues is unclear. Using mouse models, we simulated acquired and genetic HO, investigating the innate immune system's role in bone formation. Single-cell transcriptomics and imaging suggest early collaboration between macrophages and mesenchymal cells, fostering bone formation.
The seminar is OPEN to everyone.
tags: #BtBsSeminar , #BtBsUNIMIB , #BtBsSeminars
per informazioni: infobtbs@unimib.it
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