P17 - Glucosinolates as nutraceuticals: Process optimization and scale-up of Bio-based microbial production of glucobrassicin

Maestroni L.¹, Butti P.¹, Branduardi P.¹

P18 - Engineered hybrid hydrogels as 3D bioprintable platform for preclinical investigations

Magli S.¹, Crippa L.², Ballarini E.², Smith A.², Cavaletti G.², Magni F.², Bertini S.³, Cosentino C.³, Nicotra F.¹, Russo L.¹

P19 - Development of a sustainable bioprocess for the production of Vitamin B9

Mastella L.¹, Bertacchi S.¹, Senatore VG.¹, Labra M.¹, Beltrani T.², Branduardi P.¹

P20 - Protein metabolite interaction and metabolic flux sensing are involved in glucose control of Snf1/AMPK activity

Milanesi R.¹, Tripodi F.¹, Coccetti P.¹

P21 - Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse embryonic fibroblasts

Oldani M.¹, Manzoni M.², Villa A.M.¹, Stefanini F.M.³, Melchioretto P.⁴, Monti E.², Forcella M.¹ ,Urani C.^4,5, Fusi P.^1,5

P22 - A Sox2-Fos-Socs3 gene regulatory network controls the self-renewal of Neural Stem Cells

Pagin M.¹, Giubbolini S.¹, Pernebrink M.^2,5, Sambruni G.^1,3, Barone C.¹, Pitasi M.¹, Mercurio S.¹, Ottolenghi S.¹, Pavesi G.³, Wei CL.⁴, Cantù C.^2,5, Nicolis SK.¹

P23 - Development of ultrasound assisted solid liquid extraction method for the recovery of bioactive compounds from cocoa shell by-product as natural source of functional ingredient

Pagliari S.¹, Rastrelli L. ², Campone L.¹

P24 - Healthy compounds from vegetable matrices: an overview ranging from biodiversity to by-products

Panzeri D.¹, Pagliari S.¹, Giustra CM.¹, Magoni C.¹, Guzzetti L.¹, Sacco G.¹, Bruni I.¹, Forcella M.¹, Fusi P.¹, Labra M.¹

P25 - The rediscovery of trehalose production by Saccharomyces cerevisiae

Pessina A.¹, Vanoni M.^1,2, Brambilla L.^1,2

P26 - Living in the metropolis: how landscape anthropization shapes morphology of two charismatic insect pollinators

Pioltelli E.¹, Biella P.¹, Tommasi N.¹, Galimberti A.¹ Labra M.¹

P27 - Role of DNA damage response in R-Loops recognition and signalling

Pizzul P.¹, Bonetti D.¹

P28 - Evaluation of the prebiotic effects of new natural extracts on beneficial bacteria associated with human health

Racca T.¹, De Giani A.¹, Di Gennaro P.¹

P29 - Multimodal enhanced in vivo imaging of pancreatic β-cells using PGA-chitosan based nanoparticles

Rossi L.¹, Russo L.¹, Pignatelli C.¹, Kerekes K.², Körhegyi Z.², Bodnar M.², Kocsi J.², Lindheimer F.³, Lindner M.³, Lindner S.³, Bartenstein P.³, Ziegler S.³, Nicotra F.¹

P30 - Development of vault-based nanovectors in Pichia pastoris and antibody-mediated targeting investigation on cancer cell lines

Tomaino G.¹, Pozzi M.¹, Mazzucchelli M.¹, Agresta A.¹, Vanoni M.^1,2, Frascotti G.¹, Tortora P.¹

P31 - DALIS in aging, inflammation and neurodegeneration

Torinesi RS.¹, Gatti E.², Grandori R.¹, Vai M.¹, Orlandi I.¹

P32 - Identification of novel gene asset of Rhodococcus opacus R7 for polyethylene degradation by RNA-seq approach

Zampolli J.¹, Orro A.², Milanesi L.², Di Gennaro P.¹

P33 - Synthesis Optimization and Biological Characterization of New Toll-Like Receptor 4 (TLR4) Modulators

Alessio Romerio¹, Andrea Luraghi¹, Nicolé Gotri¹, Valentina Artusa¹, Simona D’amato¹, Francesco Peri¹

P01 - Identification of spectroscopic markers of amyotrophic lateral sclerosis

Ami D.¹, Ambrosio F.¹, Natalello A.¹

P02 - Roasting process does not affect anti-inflammatory properties of coffee extracts

Artusa V.¹, Ciaramelli C.¹, Palmioli A.¹, Airoldi C.¹, Peri F.¹

P03 - Dissecting the role of serine in neurological disorders

Badone B.¹, Tripodi F.¹, Coccetti P.¹

P04 - Biofabrication of a vascularized 3D tissue in vitro model

Barbugian F.^1,2, Bodet T. ², Moroni L.², Russo L.¹, Nicotra F.¹

P05 - Enzymatic hydrolysis of Camelina sativa meal for carotenoids production by the yeast Rhodosporidium toruloides

Bertacchi S.¹, Cantù C.¹, Branduardi P.¹

P06 - Charge patterning and phase separation propensity in IDPs: is there a possible interplay?

Bianchi G.¹, Dell’Orto L.², Longhi S.², Brocca S.¹

P07 - Analysis of cadmium effect on neural cells energetic metabolism using Seahorse technology

Bovio F.¹, Forcella M.¹, Urani C.², Fusi P.¹

P08 - Study of extracellular matrix glycosignature in dictate cell fate using 3D glyco-conjugate biomaterials

Cadamuro F.¹, Chiodo F.², Nicotra F.¹, Russo L.¹

P09 - Three-dimensional models for the study of breast cancer metabolism

Pasquale V.^1,2*, Campioni G.^1,2*, Ducci G.^1,2, Savore A.^1,2, Sacco E.^1,2, Vanoni M.^1,3

P10 - Dual role of Dpb4 in the DNA damage response

Casari E.¹, Gobbini E.¹, Calabrese S.¹, Clerici M.¹, Longhese MP.¹

P11 - NMR-based dissection of cocoa anti-amyloidogenic activity

Ciaramelli C.^1,4, Palmioli A.^1,4, De Luigi A.², Colombo L.², Sala G.^3,4, Salmona M.2, Airoldi C.^1,4

P12 - Developmental effects of β2V287L nAChR subunit on pyramidal neuron morphology in the neocortex

Colombo G.¹, Modena D.², Coatti A.^1*, Amadeo A.², Becchetti A.¹

P13 - Effects of Prebiotics and Probiotics on Human Gut Microbiota and Related Immune System: A Study on Healthy and Elderly Subjects

De Giani A.¹, Sandionigi A.¹, Zampolli J.¹, Michelotti A.², Tursi F.², Labra M.¹, Di Gennaro P.¹

P14 - Cardoon roots valorization by combined microbial biotransformation for lactic acid production

Di Lorenzo RD.¹, Branduardi P.¹

P15 - High-resolution imaging and high-content analysis of mitochondrial efficiency and OXPHOS relevance in grade II bladder cancer cells

Ducci G.^1,2, Pasquale V.^1,2, Campioni G.^1,2, Ventrici A.¹, Arrigoni E.¹, Vanoni M.^1,2, Vago R.³, Sacco E.^1,2

P16 - Mechanism of action of new synthetic Toll-Like receptor 4 agonists for the development of innovative vaccine adjuvants

Gotri N.¹, Facchini F.A.¹, Romerio A.¹, Luraghi A.¹, Peri F.¹

La sessione è RISERVATA ai frequentatori del Dipartimento di Biotecnologie e Bioscienze – UNIMIB

La richiesta di partecipazione alla sezione posters, per il personale esterno al dipartimento, sarà fatta via email direttamente al presentatore del poster al quale si e interessato.

Ami D.¹, Ambrosio F.¹, Natalello A.¹
E-mail: diletta.ami@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Amyotrophic lateral sclerosis, FTIR microspectroscopy, multivariate analysis, protein aggregation, protein misfolding, tears

Artusa V.¹, Ciaramelli C.¹, Palmioli A.¹, Airoldi C.¹, Peri F.¹
E-mail: v.artusa@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: coffee extract, phytochemicals, roasting, inflammation, cytokines

Badone B.¹, Tripodi F.¹, Coccetti P.¹
E-mail: beatrice.badone@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Alzheimer’s Disease, hiPSC-astrocytes, neural stem cells, brain tissues, metabolism

Barbugian F.^1,2, Bodet T. ², Moroni L.², Russo L.¹, Nicotra F.¹
E-mail: f.barbugian@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Institute for Technology-Inspired regenerative Medicine (MERLN), Netherlands
Keywords: Regenerative medicine, Tissue Engineering, Biofabrication, Breast cancer, Vasculogenesis, Bioprinting, Additive Manufacturing, hydrogel

Bertacchi S.¹, Cantù C.¹, Branduardi P.¹
E-mail: s.bertacchi@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Bio-based products, Renewable resources, Biorefinery, Camelina meal, Enzymatic hydrolysis, Rhodosporidium toruloides, Carotenoids

Bianchi G.¹, Dell’Orto L.², Longhi S.², Brocca S.¹
E-mail: g.bianchi31@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²CNRS and Aix-Marseille University, Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Marseille, France
Keywords: protein conformation, protein coacervation, distribution of electrostatic charges

Bovio F.¹, Forcella M.¹, Urani C.², Fusi P.¹
E-mail: f.bovio@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Department of Earth and Environmental Sciences, University of Milan Bicocca, Milan, Italy
Keywords: cadmium, Seahorse, neural cells, energetic metabolism, glycolysis

Cadamuro F.¹, Chiodo F.², Nicotra F.¹, Russo L.¹
E-mail: f.cadamuro@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Department of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands
Keywords: Glycans, Biomaterials, Extracellular matrix

Pasquale V.^1,2*, Campioni G.^1,2*, Ducci G.^1,2, Savore A.^1,2, Sacco E.^1,2, Vanoni M.^1,3
E-mail: valentina.pasquale@unimib.it, g.campioni@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
¹SYSBIO, Centre of Systems Biology, Milan, Italy
^* VP and GC equally contributed to this manuscript
Keywords: three-dimensional models, spheroids, organoids, breast cancer, metabolism

Ciaramelli C.^1,4, Palmioli A.^1,4, De Luigi A.², Colombo L.², Sala G.^3,4, Salmona M.2, Airoldi C.^1,4
E-mail: carlotta.ciaramelli@unimib.it
¹ BioOrgNMR Lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
² Department of Molecular Biochemistry and Pharmacology, IRCCS- Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
³ School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
⁴ Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, Milan, Italy
Keywords: Cocoa, flavanols, NMR, anti-amyloidogenic, Aβ peptides, Alzheimer’s disease

Colombo G.¹, Modena D.², Coatti A.^1*, Amadeo A.², Becchetti A.¹
E-mail: g.colombo83@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²University of Milano, Milan, Italy
* Past affiliation
Keywords: epilepsy, sleep, nAChR, pyramidal neuron, cortex, dendrites, dendritic spines, ADSHE

De Giani A.¹, Sandionigi A.¹, Zampolli J.¹, Michelotti A.², Tursi F.², Labra M.¹, Di Gennaro P.¹
E-mail: alessandra.degiani@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²CompLife Italia, Safety and Efficacy Lab, Italy
Keywords: Clinical study, Synbiotic, Prebiotics, Probiotics, Gut Microbiota

Di Lorenzo RD.¹, Branduardi P.¹
E-mail: raffaella.dilorenzo@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Cardoon, Inulin, Lactic acid, Synthetic consortium

Ducci G.^1,2, Pasquale V.^1,2, Campioni G.^1,2, Ventrici A.¹, Arrigoni E.¹, Vanoni M.^1,2, Vago R.³, Sacco E.^1,2
E-mail: g.ducci@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²SYSBIO/ISBE.IT, Centre of Systems Biology, Milan, Italy
³Urological Research Institute, Division of Experimental Oncology, IRCCS San Raffaele Hospital, Milan, Italy
Keywords: bladder cancer, energy and redox metabolism, cellular bioenergetics, mitochondrial function, oxidative stress, operetta

Gotri N.¹, Facchini F.A.¹, Romerio A.¹, Luraghi A.¹, Peri F.¹
E-mail: n.gotri@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: TLR4, synthetic molecules, vaccine adjuvants, immunostimulators

La sessione è RISERVATA ai frequentatori del Dipartimento di Biotecnologie e Bioscienze – UNIMIB

La richiesta di partecipazione alla sezione posters, per il personale esterno al dipartimento, sarà fatta via email direttamente al presentatore del poster al quale si e interessato.

Maestroni L.¹, Butti P.¹, Branduardi P.¹
E-mail: l.maestronj@campus.unimib.it
¹IndBiotech lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: glucosinolates, circular economy, process design, yeasts, synthetic biology, golden gate assembly, CRISPR-Cas9, enzymes scaffolding

Magli S.¹, Crippa L.², Ballarini E.², Smith A.², Cavaletti G.², Magni F.², Bertini S.³, Cosentino C.³, Nicotra F.¹, Russo L.¹
E-mail: s.magli1@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²School of Medicine and Surgery, University of Milano-Bicocca, Vedado al Lambro (MB), Italy
³Institute for Chemical and Biochemical Research G. Ronzoni, Milan, Italy
Keywords: Hybrid Hydrogel, Click Chemistry, Diels Alder, 3D model, Bioprinting

Mastella L.¹, Bertacchi S.¹, Senatore VG.¹, Labra M.¹, Beltrani T.², Branduardi P.¹
E-mail: l.mastella@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Laboratory for Resources Valorization (RISE), Department for Sustainability, ENEA- Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Italy
Keywords: Saccharomyces cerevisiae, Scheffersomyces stipitis, folate, metabolic engineering, residual biomasses, industrial symbiosis

Milanesi R.¹, Tripodi F.¹, Coccetti P.¹
E-mail: r.milanesi2@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Snf1/AMPK, Ras/PKA, glucose metabolism, protein metabolite interaction, signal transduction, flux sensing

Oldani M.¹, Manzoni M.², Villa A.M.¹, Stefanini F.M.³, Melchioretto P.⁴, Monti E.², Forcella M.¹ ,Urani C.^4,5, Fusi P.^1,5
E-mail: m.oldani12@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Department of Molecular and Translational Medicine (DMTM), University of Brescia, Brescia, Italy
³Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy
⁴Department of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, Italy
⁵Integrated Models for Prevention and Protection in Environmental and Occupational Health, (MISTRAL), Interuniversity Research Center, Italy
Keywords: Cadmium Carcinogenesis, Cell metabolism, DNA damage Mitochondria, Reactive oxygen species

Pagin M.¹, Giubbolini S.¹, Pernebrink M.^2,5, Sambruni G.^1,3, Barone C.¹, Pitasi M.¹, Mercurio S.¹, Ottolenghi S.¹, Pavesi G.³, Wei CL.⁴, Cantù C.^2,5, Nicolis SK.¹
E-mail: m.pagin1@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²WCMM and Department of Biomedical and Clinical Sciences, Linköping University, Sweden
³Department of Biosciences, University of Milano, Italy
⁴The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
⁵Department of Biomedical and Clinical Sciences, Linköping University, Sweden
Keywords: Sox2, transcription factor, neural stem cells, self-renewal, long-range interactions, Socs3, Fos, rescue

Pagliari S.¹, Rastrelli L. ², Campone L.¹
E-mail: stefania.pagliari@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Department of Pharmacy, University of Salerno, Fisciano (SA), Italy
Keywords: Theobroma cacao, SALLE, chemometric analysis, Methylxanthines, UHPLC-HRMS-UV

Panzeri D.¹, Pagliari S.¹, Giustra CM.¹, Magoni C.¹, Guzzetti L.¹, Sacco G.¹, Bruni I.¹, Forcella M.¹, Fusi P.¹, Labra M.¹
E-mail: davide.panzeri@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: bioprospecting, sustainability, bioactivity, by-products, biodiversity

Pessina A.¹, Vanoni M.^1,2, Brambilla L.^1,2
E-mail: a.pessina9@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²SYSBIO – Centre of Systems Biology, Milan, Italy
Keywords: Trehalose, S. cerevisiae, Glutamic acid, fed-batch, Metabolic engineering

Pioltelli E.¹, Biella P.¹, Tommasi N.¹, Galimberti A.¹ Labra M.¹
E-mail: e.pioltelli@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Pollination, Urbanization, Landscape, Ecology, Morphology

Racca T.¹, De Giani A.¹, Di Gennaro P.¹
E-mail: tiziana.racca@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
Keywords: Prebiotics, Probiotics, Natural extracts, Health

Rossi L.¹, Russo L.¹, Pignatelli C.¹, Kerekes K.², Körhegyi Z.², Bodnar M.², Kocsi J.², Lindheimer F.³, Lindner M.³, Lindner S.³, Bartenstein P.³, Ziegler S.³, Nicotra F.¹
E-mail: l.rossi58@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²BBS Nanotechnology, Debrecen, Hungary
³Department of Nuclear Medicine, Faculty of Medicine, University Hospital LMU, Munich, Germany
Keywords: in vivo targeting, multimodality, nanoparticles, pancreas, click chemistry

Tomaino G.¹, Pozzi M.¹, Mazzucchelli M.¹, Agresta A.¹, Vanoni M.^1,2, Frascotti G.¹, Tortora P.¹
E-mail: g.tomaino3@campus.unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²SYSBIO – Centre of Systems Biology, Italy
Keywords: Pichia pastoris, vault nanoparticle, cell targeting, breast cancer

Zampolli J.¹, Orro A.², Milanesi L.², Di Gennaro P.¹
E-mail: jessica.zampolli@unimib.it
¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
²Institute of Biomedical Technologies, National Research Council, CNR, ITB-CNR, Italy
Keywords: Rhodococcus genus, RNA-seq analysis, biodegradation, plastic, polyethylene

Alessio Romerio¹, Andrea Luraghi¹, Nicolé Gotri¹, Valentina Artusa¹, Simona D’amato¹, Francesco Peri¹
E-mail: a.romerio1@campus.unimib.it
¹ Università di Milano-Bicocca, Department of Biotechnology and Bioscience, Milano
Keywords: <i>TLR4, Innate immunity, Inflammation, Medicinal Chemistry, Organic Chemistry</i>

Questi Graphical Abstract sono stati redatti da alcuni studenti di laurea magistrale in tesi nel nostro dipartimento. Si tratta del progetto e dei risultati del loro lavoro di tesi, esposti in maniera tale da comunicarli a un pubblico più ampio di quello strettamente scientifico. Questi Graphical Abstract fanno parte dell'iniziativa "My Thesis in Bicocca" (#myTHESISinBICOCCA).

PREMIO GRAPHICAL ABSTRACT BtBsDay2020

Federica Malighetti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Cristiana Barone

Gruppo di Ricerca: Prof.ssa Silvia Nicolis

Alessandro Marchetti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Marco Mangiagalli

Gruppo di Ricerca: Prof.ssa Marina Lotti

Lorenzo Marradi, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Lorenzo Rossi

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

Nicoletta Murenu, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Sofia Magli

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

Mattia Pitasi, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Miriam Pagin

Gruppo di Ricerca: Prof.ssa Silvia Nicolis

Giovanni Schiesaro, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

Gruppo di Ricerca: Dr.ssa Chiara Damiani

Vittorio G. Senatore, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Luca Mastella

Gruppo di Ricerca: Prof.ssa Paola Branduardi

Martina Simonti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Simone Meneghini

Gruppo di Ricerca: Prof. Andrea Becchetti

Ilaria Valotti, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

coautore: Francesca Cadamuro

Biorganic Chemistry Group: Prof. Francesco Nicotra, Dr.ssa Laura Russo

Marzia Zamprogno, Dipartimento di Biotecnologie e Bioscienze, UNIMIB, Italia

Laboratorio di Biologia Molecolare Animale: Prof.ssa Silvia Barabino