Seminario - Biotecnologie e Bioscienze - giovedì 9 novembre 2023, 16.30, edificio U4-TELLUS, aula U4-03 / Webex.
Emanuele Azzoni, Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano‐Bicocca
Abstract
Recent reports showed how long-term hematopoietic stem cells (HSCs) do not reside at the top of the fetal hematopoietic hierarchy, highlighting unexpected complexity in the establishment of the hematopoietic system. Through a genetic fate-mapping strategy in mouse, we identify a wave of fetal-restricted hematopoietic stem/progenitor cells (HSPCs) that contribute the majority of lympho-myeloid cells during pre-natal development. Moreover, we investigate Juvenile Myelomonocytic Leukemia (JMML) as a model of a pediatric leukemia with pre-natal origin, and show how embryonic HSPCs display differential susceptibility to transformation upon acquisition of JMML driver mutations.
Ospite: Antonella Ronchi
LINK per partecipare al seminario: https://unimib.webex.com/unimib-it/j.php?MTID=m8532495d106e8bea419a11c202878ea5
password: day09 (32909 da telefoni e sistemi video)
Il seminario è APERTO a tutti.
tag: #BtBsSeminars , #RonchiLab_BtBs