BtBs seminar - Dissecting heterogeneity of pre-natal hematopoiesis in health and disease

Emanuele Azzoni, School of Medicine And Surgery, University of Milano‐Bicocca

Recent reports showed how long-term hematopoietic stem cells (HSCs) do not reside at the top of the fetal hematopoietic hierarchy, highlighting unexpected complexity in the establishment of the hematopoietic system. Through a genetic fate-mapping strategy in mouse, we identify a wave of fetal-restricted hematopoietic stem/progenitor cells (HSPCs) that contribute the majority of lympho-myeloid cells during pre-natal development. Moreover, we investigate Juvenile Myelomonocytic Leukemia (JMML) as a model of a pediatric leukemia with pre-natal origin, and show how embryonic HSPCs display differential susceptibility to transformation upon acquisition of JMML driver mutations.

Host: Antonella Ronchi

LINK to join the seminar:  https://unimib.webex.com/unimib-it/j.php?MTID=m8532495d106e8bea419a11c202878ea5

password:  day09 (32909 da telefoni e sistemi video)

The seminar is OPEN to all.

tag:   #BtBsSeminars , #RonchiLab_BtBs