BtBs seminar - Mechanobiology of the Tumor Ecosystem: from Fibrolasts to Immune cells and Cancer cells

Nils Gauthier, IFOM - Mechano-Oncology Lab, The AIRC Institute of Molecular Oncology

Nils Gauthier Lab

Our goal is to understand the roles of mechanical signals generated at the interface between membrane and cytoskeleton during tumor-associated biological events.
This way of thinking about cancer is directly linked to the field of mechanobiology (i.e. the study of the role of mechanical forces in biological events) and to the lack of knowledge on the potential role of physical forces and parameters during tumor progression.
In this seminar I will present what our lab has done to understand how tumor can be seen has an ecosystem where mechanobiology plays a major role in supporting tissues (fibroblasts) immune functions (Macrophages) and for sur Cancer cells (here we will talk about Glioblastoma)

Some key publications of the lab on Glioblatoma, Fibroblast and Macrophages:

-Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion. Monzo P, Crestani M, Chong YK, Ghisleni A, Hennig K, Li Q, Kakogiannos N, Giannotta M, Richichi C, Dini T, Dejana E, Maiuri P, Balland M, Sheetz MP, Pelicci G, Ang BT, Tang C, Gauthier NC. Dev Cell. 2021 Oct 25.  DOI: 10.1016/j.devcel.2021.09.007
-Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse. Ghisleni A, Galli C, Monzo P, Ascione F, Fardin MA, Scita G, Li Q, Maiuri P, Gauthier NC. Nat Commun. 2020 Oct 9. DOI: 10.1038/s41467-020-18825-7
-Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis. Barger SR, Reilly NS, Shutova MS, Li Q, Maiuri P, Heddleston JM, Mooseker MS, Flavell RA, Svitkina T, Oakes PW, Krendel M, Gauthier NC. Nat Commun. 2019 Mar 19. DOI: 10.1038/s41467-019-09104-1

Host: Metello Enzo Innocenti

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LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=m5e05f174aa53185f6747fb1bc3029e15

password:  day01 (32901 da telefoni e sistemi video)

Il seminario è APERTO a tutti.

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