Seminario - Biotecnologie e Bioscienze - Giovedì 26 febbraio 2026, 16.30, edificio U3-BIOS, aula U3-09.
Sara Sdelci, Centre for Genomic Regulation (CRG) and Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Abstract
Genome integrity depends on the efficient repair of DNA lesions, yet the metabolic underpinnings of how the nucleus supports this process remain underexplored. Drawing on our recent findings, I will discuss how nuclear metabolism plays key roles in orchestrating the DNA damage response. Specifically, I will highlight how nuclear cofactor availability, metabolite-derived building blocks, nuclear energy and redox buffering within the nuclear compartment influence chromatin-associated repair events, damage-sensing signalling and the kinetics of lesion resolution. I will also address how perturbations in these nuclear metabolic pathways compromise repair fidelity and can be exploited as vulnerabilities in disease contexts such as aggressive cancer subtypes. By reframing metabolism and DNA repair as intimately connected in the nuclear space, I will present a unified perspective on how cells coordinate energy, redox and biosynthetic demands to maintain genome stability.
Ospite: Ferdinando Chiaradonna
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