BtBs Seminar - Towards 3Rs: use of alternative methods for the validation of biomedical and cosmeceutical nanodrugs

Luisa Fiandra, Assistant Professor of Clinical Biochemistry at University of Milano-Bicocca (Department of Biotechnology and Biosciences)

Fiandra’s Lab

The use of animals in biomedical research is generally justified by the potential high advantage to the health of humans, other animals or environment. Nevertheless, ethical issues require scientists to limit animal employment in their research. That’s why today 3Rs (Replacement, Reduction and Refinement) have become established worldwide as the ethical approach to governing animal-dependent science. According to 3Rs, alternatives methods have been improved in order to reduce or, wherever possible, to replace the use of animals, but also to limit their suffering.

Among alternative biological methods, 3D cells cultures are highly powerful since they can reproduce tissue complexity, provide good reproducibility and the material is virtually unlimited. Over the last years, different 3D cell models have been employed for the validation of drug candidates, including innovative nanomaterials for biomedical and cosmeceutical devices. In details, advanced cell models have been developed to determine the permeability of nanotheraputics across the biological barriers, the therapeutic activity on pathological targets, but also to determine the safety profile of the newly designed nanoformulations.

Examples of these applications will be proposed, with a focus on nanoformulations for blood-brain barrier overcoming and tumor management, and on the use of reconstructed 3D skin models to disclose the possible adverse impacts of nanocosmetics. Toxicological studies on Zebrafish embryos will be also proposed to demonstrate the potential of this alternative experimental model for the safe-by-design development of biomedical nanodevices.

LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=mba77e446872bd5d9f82336077f6b3cf0

password:   day10   (32910 da telefoni)

Il seminario è APERTO a tutti.

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