BtBs seminario - Rejuvenated blood stem cells extend lifespan of aged mice

Carolina Florian, ICREA Research Professor, Stem Cell Aging Group, Regenerative Medicine Program, The Bellvitge Institute for Biomedical Research (IDIBELL), Barcelona, Spain.

Florian Group

One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However, evidence that somatic stem cells can be targeted in vivo to extend lifespan is still lacking.
Recently, we provided proof‐of‐concept evidence that a short systemic treatment with a specific Cdc42 inhibitor (CASIN) rejuvenates aged blood stem cells in vivo, exerting a broad systemic effect sufficient to extend murine health and lifespan.
Overall, our data supports that increasing the regenerative potential of endogenous aged somatic stem cells represents an important strategy for rejuvenating tissues and improving health‐ and lifespan in the elderly.

Ospite: Antonella Ronchi

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Short CV
M. Carolina Florian is ICREA Research Professor and leads the Stem Cell Aging group at IDIBELL and PCMR-C. She obtained her Master of Science in Pharmaceutical Biotechnology and her PhD in Endocrinology from the University of Milan, Italy. She did her postdoctoral training in Hematopoietic Stem Cell Biology at the University of Ulm, Germany.
Her research strongly challenges the concept that aging is an irreversible process. She investigates the role of the epigenetic remodeling and of the stem cell microenvironment in driving aging of somatic stem cells. Her work demonstrates that it is possible to target aging and functionally rejuvenate stem cells and tissues to extend health- and lifespan.
 

Key words: stem cells, ageing, microenvironment, epigenetic, chromatin, cell polarity, symmetry of division, leukemia, regenerative medicine

LINK per partecipare al seminario: https://unimib.webex.com/unimib-it/j.php?MTID=medffc832091a17a78e0bd005587020e2

password:  day26 (32926 da telefoni e sistemi video)

Il seminario è APERTO a tutti.

tag:   #BtBsSeminars , #RonchiLab_BtBs