01 dicembre 2022

BtBs Seminar - Notch signaling and control of Regulatory T cell function in tissue inflammation

Raffaele De Palma, giovedì 1 dicembre, 2022, ore 16:30, edificio BIOS, aula U3-04/ Webex

Biotechnology and Biosciences Seminar - giovedì 1 dicembre, 2022, ore 16:30, edificio BIOS, aula U3-04/ Webex

Raffaele De Palma, Dipartimento di Medicina interna e Specialità mediche (DIMI), Università degli Studi di Genova e Istituto di Biochimica e Biologia Cellulare (IBBC-CNR), Napoli.

Abstract
Seminari-BtBs-UNIMIB

Chronic tissue inflammatory diseases, triggered by pathogens or in the context of autoimmune and degenerative diseases, represent a huge medical and societal burden. Initiation and persistence of these diseases can be due to subversion of T regulatory cell (Treg) function, due to disease-associated mechanisms dysregulating regulatory function of Treg that could be targeted to develop effective therapies. I will present the critical role of TR cell-intrinsic Notch signaling in licensing tissue inflammation in viral and autoimmune diseases, showing that individual receptors direct Treg responses depending on the inflammatory triggers so promoting inflammation in a tissue-specific manner.

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