10 novembre 2022

BtBs Seminar - Multiscale analysis of the Arp2/3 complex and mDia formins: from basic biology to cancer and back

Metello Innocenti - giovedì 10 novembre, 2022, ore 16:30, edificio TELLUS, aula U4-01 / Webex

Biotechnology and Biosciences Seminar - giovedì 10 novembre, 2022, ore 16:30, edificio TELLUS, aula U4-01 / Webex

Metello Innocenti, Heidelberg University Biochemistry Center (BZH)

Abstract
Metello seminar BtBs

Mammalian cells sense and react to external signals by changing shape, behaviour, and even fate. These adaptive responses heavily rely on the actin cytoskeleton and go frequently awry in cancer and other human diseases. We study two druggable and ubiquitously expressed actin-assembly machineries, Arp2/3 complex and mDia formins, which regulate the formation of specialized protrusions and invaginations on the plasma membrane. I will present work from my lab that has contributed to elucidating how actin controls cell migration, clathrin-mediated endocytosis, and signalling in normal cells, and how dysregulation of actin dynamics impacts on homeostasis and carcinogenesis in epithelial tissues.

LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=mf9e95139a2322e0288c837df282a82ec

password:  day10 (32910 da telefoni)

Il seminario è APERTO a tutti.

tag:   #BtBsSeminars #InnocentiLab_BtBs

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