BtBs Seminar - High Mobility Group Box 1 (HMGB1) and sterile inflammation: From tissue damage & regeneration to cancer immunity

Marco E. Bianchi, School of Medicine, San Raffaele University

A single protein, HMGB1, directs the triggering of inflammation, innate and adaptive immune responses, and tissue healing after damage.
HMGB1 is the best characterized damage-associated molecular pattern (DAMP), molecules that are normally inside the cell but are released after cell death, and allow the immune system to distinguish between antigens that are dangerous or not.
Moreover, severely stressed cells actively release HMGB1 via a dedicated secretion pathway. Extracellular HMGB1 exists in multiple oxidation states, which direct the mutually exclusive choices of different binding partners and receptors.
Immune cells are first recruited to the damaged tissue and then activated by HMGB1; thereafter, HMGB1 supports tissue repair and healing.
Inevitably, HMGB1 also orchestrates the support of stressed but illegitimate tissues: tumors.
Concomitantly, HMGB1 enhances the immunogenicity of mutated proteins in the tumor, promoting anti-tumor responses and immunological memory.

LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=m049bb9e6b3fdd4cb9bb636c31fc3de9d

password:  day16 (32916 da telefoni)

Il seminario è APERTO a tutti.

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