23 giugno 2022

BtBs Seminar - Functional roles of deubiquitinating enzymes in normal and malignant hematopoiesis

Elisabetta Citterio, giovedì 23 giugno, 2022, ore 16:30, aula U3-04 / Webex

Biotechnology and Biosciences Seminar - giovedì 23 giugno, 2022, ore 16:30, aula U3-04 / Webex

Elisabetta Citterio, Visiting Researcher at University of Milano-Bicocca, Department of Biotechnology and Biosciences


Deubiquitinating enzymes (DUBs) are specialized proteases that remove ubiquitin from substrates, maintaining protein homeostasis and signalling in cells. DUB deregulation affects hematopoietic stem cell (HSC) maintenance.

However, thorough knowledge of DUB function during hematopoiesis is lacking. Recently, we interrogated DUB dependency in mouse hematopoietic progenitors employing in vivo siRNA screens and uncovered multiple DUBs potentially required for HSC maintenance. Genetic targeting revealed USP15 as a critical DUB in safeguarding genome integrity in HSCs and leukemia cells. We will discuss these data together with advances encouraging the development of DUBs as therapeutic targets.

LINK per partecipare al seminario:  https://unimib.webex.com/unimib-it/j.php?MTID=mca9af3d0860db9819885364719007e00

password:   day23 (32923 da telefoni)

Il seminario è APERTO a tutti.

tag:   #BtBsSeminars

Gli attestati di partecipazione al seminario sono validi anche per l’acquisizione dei CFU, per altre informazioni e richiesta, visitare il link dedicato.