Seminario - Biotecnologie e Bioscienze - giovedì 12 ottobre, 2023, ore 16:30, edificio BIOS, 2do piano, aula 2025 / Webex
Luca Muzio, Neuroimmunology Unit, INSpe, Division of Neuroscience. Adjunct Professor Neuroscience, Università Vita-Salute San Raffaele, San Raffaele Scientific Institute, Milan
Abstract
Alterations of the endolysosomal and autophagic pathways have been associated with several disorders, including some neurological conditions. Accordingly, defects in the endo-lysosomal pathway and in autophagy/mitophagy pathway have been observed in Alzheimer’s disease, ischemic stroke and Amyotrophic Lateral Sclerosis.
Early pathological changes in both systems compromise the removal of misfolding & aggregating proteins as well as increase damaged mitochondria, leading to a gradual accumulation of defective autophagic vacuoles (AVs) and lysosome dyshomeostasis.
Relevant therapeutic strategies aiming at restoring the homoeostasis of these pathways can foster neuronal survival.
Ospite: Silvia Kirsten Nicolis
LINK per partecipare al seminario: https://unimib.webex.com/unimib-it/j.php?MTID=m648e38b4e93395fdd46982f4062b81aa
password: day12 (32912 da telefoni e sistemi video)
Il seminario è APERTO a tutti.
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