BtBsDay2025 Poster session (P46-P60)

Giornata del Dipartimento di Biotecnologie e Bioscienze 2025

Programma BtBsDay 2025

Poster session - Galleria della Scienza (U3-U4)

P46 - Redox-mediated causal connection between ferroptosis and aging in Caenorhabditis elegans: a role for fard-1 and dhs-25

Poster presenter – Roberta Pensotti

Roberta Pensotti1, Barbara Sciandrone1, Federica Bovio1, Laura Schröter2, Silvia Maglioni2, Leonie Thewes5, Matilde Emma Forcella1, Paola Alessandra Fusi1, Andrea Rossi2, Carsten Berndt5, Natascia Ventura2, Maria Elena Regonesi1
E-mail: r.pensotti1@campus.unimib.it
1Department of Biotechnology and Biosciences BtBs, University of Milano-Bicocca, Milan, Italy
2Leibniz Research Institute for Environmental Medicine IUF, Düsseldorf, Germany
5 Department of Neurology, Heinrich Heine University, Düsseldorf, Germany

Keywords: aging, ferroptosis, redox homeostasis, frataxin, oxidative stress, antioxidant systems, lipid peroxidation, Caenorhabditis elegans

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P46_ABSTRACT POSTER_Pensotti Roberta

P47 - Comparative microbial and functional characterization of kombucha from different starter SCOBYs

Poster presenter – Susanna Perotti

Susanna Perotti1, Francesca Sabatini2, Immacolata Serra1, Heiko Lange2, Federica Facciotti1, Paola Branduardi1 and Valeria Mapelli1
E-mail: s.perotti7@campus.unimib.it
1 University of Milano-Bicocca, Department of Biotechnology and Biosciences, P.zza della Scienza 2, 20126Milan, Italy
2 University of Milano-Bicocca, Department of Earth and Environmental Sciences, P.zza della Scienza 1,20126 Milan, Italy

Keywords: Kombucha, SCOBY, yeast, biodiversity, health benefits

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P47_ABSTRACT POSTER_Perotti Susanna

P48 - Transforming plastic waste: harnessing E. coli for sustainable PET recycling and valorisation

Poster presenter – Alex Pessina

Alex Pessina 1, Isabella Cecilia Rizzo1, Caren Battaglia3, Davide Miani3, Chiara Damiani 1,2, Luca Brambilla 1,2, Gianluca Molla 3, Elena Rosini 3, Loredano Pollegioni 3, Marco Vanoni 1,2
E-mail: alex.pessina@unimib.it
1 Department of Biotechnology and Biosciences, University of Milano-Bicocca
2 SYSBIO – Centre of Systems Biology, Italy
3 “The Protein Factory 2.0” Lab, Department of Biotechnology and Life Sciences, University of Insubria

Keywords: PET; E. coli; CRISPR/Cas9; Bioreactor; constraint-based techniques

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P48_ABSTRACT POSTER_Pessina Alex

P49 - Unveiling the potential of inactivated probiotics: adhesion and immunomodulatory properties of selected Lactobacilli

Poster presenter – Elena Pierallini

Elena Pierallini1, Giacomo Mantegazza1,2, Beatrice Pizzelli1, Simone Guglielmetti1
E-mail: e.pierallini@campus.unimib.it
1 bEat Lab, Department of Biotechnology and Biosciences (BtBs), University of Milano-Bicocca, Piazza Della Scienza 4, 20126 Milan, Italy
2 Division of Food Microbiology and Bioprocesses, Department of Food, Environment, and Nutritional Science, Università Degli Studi Di Milano, Via Celoria 2, 20133 Milan, Italy

Keywords: Probiotics, Paraprobiotics, Postbiotics, Caco-2, NF- HEK, Non-Communicable Diseases

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P49_ABSTRACT POSTER_Pierallini Elena

P50 - Isolation and characterization of novel bacterial strains for the development of fermented plant-based products

Poster presenter – Beatrice Pizzelli

Giacomo Mantegazza1,2, Beatrice Pizzelli1, Simone Guglielmetti1
E-mail: b.pizzelli@campus.unimib.it
1 μbEat lab, Department of Biotechnology and Biosciences (BtBs), University of Milano-Bicocca, Piazza della Scienza 4, 20133, Milan, Italy
2 Department of Food, Environment, and Nutritional Science, Università degli Studi di Milano, Via Celoria 2, 20133, Milan, Italy

Keywords: lactic acid bacteria, plant-based food, fermented foods, dairy milk alternatives

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P50_ABSTRACT POSTER_Pizzelli Beatrice

P51 - From Bulk Analysis to Single Cell: Dissecting Proliferative and Metabolic Landscape in Cancer Spheroids

Poster presenter – Simone Ponzetto

Simone Ponzetto1, Gloria Campioni1,2, Giacomo Ducci1,2, Valentina Pasquale1,2, Bruno Galuzzi1,2, Deborah D'Aliberti3, Giuseppe Rocca1, Francesca Granucci1, Chiara Damiani1,2, Rocco Piazza3, Elena Sacco1,2, Marco Vanoni1,2
E-mail: s.ponzetto@campus.unimib.it
1 Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
2 SYSBIO-ISBE-IT, Europe, Milan, Italy
3 School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

Keywords: Spheroids, Cancer, Transition, Metabolism, Immunofluorescence, Bioinformatics

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P51_ABSTRACT POSTER_Ponzetto Simone

P52 - Multimodal analysis of tissue resident dendritic cells reveals the immunosuppressive role of DCs type 3 in human NSCLC and a mouse lung tumor model

Poster presenter – Giuseppe Rocca

Giuseppe Rocca1, Anna Celant1, Maria Sonechkina2,3, Giulia Stucchi1, Marco Galli1, Stefano Cozzi1, Laura Marongiu1, Erica Marcandalli1, Francesco Lapi1, Alessia Donato1, Giulia Protti1, Chiara Damiani1, Metello Innocenti1, Francesca Granucci1
E-mail: giuseppe.rocca@unimib.it
1 Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
2 University of Milan, Milan, Italy
3 Politecnico di Milano, Milan, Italy

Keywords: Conventional dendritic cells (cDCs), Dendritic cell type 3 (DC3), Non-small cell lung cancer (NSCLC), CITE-seq, scRNA-seq, Trajectory inference, Immune regulation

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P52_ABSTRACT POSTER_Rocca Giuseppe

P53 - Characterization of the role of the SOX2 transcription factor in neurons of the visual thalamus: insights into developmental visual disorders

Poster presenters – Guido Rovelli and Sarah Placida

Guido Rovelli1, Sarah Placida1, Ilaria Fontana1, Mario Rizzuto1, David Volgarino1, Alessandra Gambacurta1, Giulio Pavesi2, Claudio Cantù3, Silvia K. Nicolis1, Sara Mercurio1
E-mail: g.rovelli@campus.unimib.it; sarah.placida@unimib.it
1Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan Italy
2Department of Biosciences, University of Milan, Milan Italy
3Department of Biomedical and Clinical Sciences, Linköping University, Linköping Sweden

Keywords: Sox2, mouse, visual system, CUT&RUN, neuron

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P53_ABSTRACT POSTER_Rovelli Guido and Placida Sarah_RESERVED_Confidential Information

P54 - “Lens sana in corpore sano”: a preliminary study on the properties of Lentil protein extract and evaluation as a functional food

Poster presenters – Chiara Sartirana and Alessia Nettis

Chiara Sartirana1, Alessia Nettis1, Barbara Sciandrone1, Maria Elena Regonesi1, Matilde Forcella1, Paola Fusi1 and Lorenzo Guzzetti1
E-mail: chiara.sartirana@unimib.it, a.nettis@campus.unimib.it
1 Dipartimento di Biotecnologie e Bioscienze, Università degli Studi Milano-Bicocca, Piazza della Scienza 2,20126 (Milano)

Keywords: protein extraction, digestive process, lipid accumulation, HepG2 cells, C.elegans

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P54_ABSTRACT POSTER_Sartirana Chiara and Nettis Alessia

P55 - Poo power: the value of vertebrate diets for measuring the biological control ecosystem service in urban environments

Poster presenter – Elisa Scaglioni

Scaglioni E. 1, Ramazzotti F. 1,2, Galimberti A. 1,2, Caprio E. 3, Rubolini D. 4, Tommasi N. 1,2, Ficetola F. 4, Biella P. 1
E-mail: e.scaglioni1@campus.unimib.it
1 Università degli Studi di Milano-Bicocca, Milano, Italia
2 National Biodiversity Future Center (NBFC), Palermo, Italia
3 Università degli Studi di Torino, Torino, Italia
4 Università degli Studi di Milano Statale, Milano, Italia

Keywords: vertebrate diet, DNA metabarcoding, ecosystem services, species interactions, urbanization, sustainability

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P55_ABSTRACT POSTER_Scaglioni Elisa

P56 - Revealing Probiotic Benefits for Healthy Aging Through Caenorhabditis elegans

Poster presenter – Barbara Sciandrone

Barbara Sciandrone1, Diletta F. Squarzanti2, Patrizia Malfa2, Maria E. Regonesi1
E-mail: barbara.sciandrone@unimib.it
1 Università degli Studi di Milano-Bicocca, Milano
2 SynBalance S.r.l., Origgio (VA)

Keywords: Caenorhabditis elegans, probiotics, LAB, aging

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P56_ABSTRACT POSTER_Sciandrone Barbara

P57 - Escherichia coli cell factory for producing an enantioselective enzyme used in the synthesis of industrial building blocks

Poster presenter – Beatrice Serati

Beatrice Serati1, Mirko Frigerio Verga1, Daniela Bucchieri1, Immacolata Serra1, Valeria Mapelli1, Paola Branduardi1
E-mail: b.serati@campus.unimib.it
1 Univerisity of Milano-Bicocca, Italy

Keywords: synthetic biology, cell factories, microbiology, enantioselective enzyme, secretion, Escherichia coli

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P57_ABSTRACT POSTER_Serati Beatrice

P58 - Uncovering Regulatory Mechanisms in FET Protein Knockout Cells via ISMARAmotif Analysis

Poster presenter – Roman Shaposhnikov

Shaposhnikov Roman1,5, Marc-David Ruepp2, Tatjana Zoller2, Alex Graudenzi3,4, Silvia Barabino1, Raphaelle Luisier5,6
E-mail: roman.shaposhnikov@unimib.it
1.Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126, Milan, Italy.
2.United Kingdom Dementia Research Institute Centre, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 5 Cutcombe Rd, London SE5 9RT, UK.
3.Department of Informatics, Systems and Communication, Università degli Studi di Milano-Bicocca, Milan, Italy.
4.B4-Bicocca Bioinformatics Biostatistics and Bioimaging Centre, Università degli Studi di Milano-Bicocca, Milan, Italy.
5.Idiap Research Institute, Martigny, 1920, Switzerland.
6.SIB Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.

Keywords: FET proteins, ISMARAmotif analysis, gene regulation, transcription factor activity

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P58_ABSTRACT POSTER_Shaposhnikov Roman

P59 - Single-cell analysis reveals distinct differentiation trajectories and immunoregulatory roles of DC3 subsets in NSCLC

Poster presenter – Maria Sonechkina

Maria Sonechkina1,2, Giuseppe Rocca3, Francesco Lapi3, Anna Celant3, Erica Marcandalli3, Marco Galli3, Stefano Cozzi3, Giulia Stucchi3, Laura Marongiu3, Alessia Donato3, Giulia Protti3, Metello Innocenti3, Chiara Damiani3, Francesca Granucci3
E-mail: maria.sonechkina@unimib.it
1 University of Milan, Milan, Italy
2 Politecnico di Milano, Milan, Italy
3 Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy

Keywords: Conventional dendritic cells (cDCs), Dendritic cell type 3 (DC3), Non-small cell lung cancer (NSCLC), CITE-seq, scRNA-seq, Trajectory inference, Immune regulation

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P59_ABSTRACT POSTER_Sonechkina Maria

P60 - Identification of new sustainable biomolecules with neuroprotective effects: a multifaceted screening of the Mediterranean biodiversity

Poster presenter – Giorgia Spandri

Giorgia Spandri1, Alessia Lambiase1,2, Hind Moukham1, Elisa Toini1,2, Fabrizio Grassi1,2, Giovanni Zecca1,2, Massimo Labra1,2, Farida Tripodi1,2 and Paola Coccetti1,2
g.spandri@campus.unimib.it
1 University of Milano Bicocca, Department of Biotechnology and Biosciences, Milano, Italy
2 National Biodiversity Future Center (NBFC), Palermo, Italy

Keywords: S. cerevisiae, human neuroblastoma cells, Parkinson’s disease, bioactive molecules, vegetal biodiversity, age-related diseases, protein aggregation, α-synuclein

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P60_ABSTRACT POSTER_Spandri Giorgia

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