Seminario - Biotecnologie e Bioscienze - Giovedì 29 gennaio 2026, ore 16:30, edificio BIOS-U3, aula U3-09
Cristina Mazzoni, Department of Biology and Biotechnology ‘‘Charles Darwin’’, Sapienza University of Rome.
Abstract
Saccharomyces cerevisiae serves as a model to study human cellular processes, such as aging and programmed cell death, owing to conserved eukaryotic pathways.
LSM (SM-like) mutants (e.g., lsm4Δ1) are valuable tools for aging research because they exhibit premature aging phenotypes, such as shorter lifespans, stress sensitivity, and increased cell death, making them excellent models for studying aging mechanisms, RNA metabolism disruption, protein aggregate clearance (proteostasis), and the efficacy of potential anti-aging conditions and compounds. These mutants were used to understand how defects in RNA processing and degradation (linked to LSM proteins) lead to cellular dysfunction and accelerated aging, often involving compromised autophagy and oxidative stress.
Ospite: Sonia Colombo
Il seminario è APERTO a tutti.
La REGISTRAZIONE ONLINE al seminario è un requisito indispensabile per chi desidera richiedere l’ATTESTATO DI PARTECIPAZIONE, che, insieme alla firma sul FOGLIO PRESENZE, confermerà l’effettiva partecipazione.
La registrazione online al seminario sarà disponibile qualche giorno prima dell'evento.