Biotechnology and Biosciences Seminar - giovedì 31 marzo, 2022, ore 16:30, solo su Webex
Elsa Zacco, Senior Researcher Marie Skłodowska-Curie Minded Fellow - Center for Human Technology, IIT, Genova
Abstract
Molecular condensation helps regulating gene expression by modulating the interactions between proteins and RNA. However, dysregulation in these interactions can result in aberrant protein liquid-to-solid phase transition and in the accumulation of toxic deposits, hallmark of neurodegeneration. In this seminar, we will focus on the interplay between proteins and RNA in phase transition and explore the use of short synthetic RNA, aptamers, to track and control the process. We will examine the case of TDP-43, whose aberrant aggregation is associated with amyotrophic lateral sclerosis, and investigate the use of RNA aptamers for studying its aggregation in vitro, in cells and in tissue.
LINK per partecipare al seminario: https://unimib.webex.com/unimib-it/j.php?MTID=m0057e7e4080f7581e0d67dcea7e766e7
password: day31 (32931 da telefoni)
Il seminario è APERTO a tutti.
tag: #BtBsSeminars
Gli attestati di partecipazione al seminario sono validi anche per l’acquisizione dei CFU, per altre informazioni e richiesta, visitare il link dedicato.