TeCSBi - 13th PhD meeting

INTRODUCTION TO MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE

Chairs: Giulia Agostinetto, Daniele D’Arrigo, Sofia Magli

09:15 – 09:45 Invited lecture (T01)
Prof. Paolo Soda, Biomedical Campus University, Rome, Italy
Artificial Intelligence and Machine Learning: an introduction

09:45 – 10:10 PhD student’s presentation: 2nd year (S01)
Martina Arici, University of Milano-Bicocca, Milan, Italy
Intracellular Ca2+ dynamics in Vascular Smooth Muscle Cells (VSMCSs) isolated from rat pulmonary artery through a non-enzymatic method

10:10 – 10:35 PhD student’s presentation: 3rd year (S02)
Erika Casari, University of Milano-Bicocca, Milan, Italy
Dual role for Dpb4 in DNA double strand break repair: regulation of end resection and DNA damage checkpoint

10:35 – 11:00 PhD student’s presentation: 2nd year (S03)
Greta Bianchi, University of Milano-Bicocca, Milan, Italy
Charge patterning is a sequence determinant for protein liquid-liquid phase separation

11:00 – 11:30 COFFEE BREAK

11:30 – 11:55 PhD student’s presentation: 2nd year (S04)
Patricia Perez Schidt, Mario Negri Institute, Milan, Italy
Synthesis of glycan coated nanoparticles for the enhanced active targeting

11:55 – 12:20 PhD student’s presentation: 3rd year (S05)
Valentina Artusa, University of Milano-Bicocca, Milan, Italy
Phytochemical profile and macrophage immunomodulatory activity of extracts from green and roasted coffee beans

12:20 – 12:45 PhD student’s presentation: 2nd year (S06)
Carlo Rinaldi, University of Milano-Bicocca, Milan, Italy
Dissecting the role of the Ku complex in the DNA damage response

12:45 – 13:45 LUNCH BREAK

PERSONALIZED MEDICINE

Chairs: Alessandra De Giani, Nicola Tommasi

13:45 – 14:30 Invited lecture and Q&A (T02)
Prof. Eduard Porta Pardo, Barcelona Supercomputing center, Spain
Personalized cancer risk prediction with polygenic risk scores: clinical and biological implications

14:30 – 14:55 PhD student’s presentation: 3rd year (S07)
Gloria Campioni, University of Milano-Bicocca, Milan, Italy
Unraveling metabolic heterogeneity of mammary carcinoma through the development of 2D and 3D culture models

14:55 – 15:20 PhD student’s presentation: 3rd year (S08)
Stefania Blasa, University of Milano-Bicocca, Milan, Italy
Scalable thermal stimulation as a versatile approach to induce neuronal differentiation

15:20 – 15:55 PhD students’ flash poster presentation: 1st year

F01. Federica Barbugian, University of Milano-Bicocca, Milan, Italy
Development of 3D printed pathophysiological in vitro device to study microenvironment effect on glioblastoma progression
Link to poster session: https://campus-unimib.webex.com/meet/f.barbugian

F02. Giulia Dellavedova, Mario Negri Institute, Milan, Italy
Overcoming PARP inhibitors drawbacks with a new generation PARP1 selective drug
Link to poster session: https://campus-unimib.webex.com/meet/g.dellavedova3

F03. Giacomo Ducci, University of Milano-Bicocca, Milan, Italy
Profiling metabolic and signaling phenotype of bladder cancer cell  lines and patient biopsies
Link to poster session: https://campus-unimib.webex.com/join/g.ducci

F04. Laura Formenti, Mario Negri Institute, Milan, Italy
OXPHOS and pharmacological response to PARP inhibition in ovarian cancer
Link to poster session: https://campus-unimib.webex.com/meet/l.formenti5

F05. Annalisa Morelli, Mario Negri Institute, Milan, Italy
Platform standardization for the detection of histopathological features in murine models of hepatic and pulmonary disorders
Link to poster session: https://campus-unimib.webex.com/meet/a.morelli9

F06. Elisa Perciballi, University of Milano-Bicocca, Milan, Italy
Is there a biochemical or molecular switch from healthy to symptomatic phenotype in Amyotrophic Lateral Sclerosis?
Link to poster session: https://campus-unimib.webex.com/meet/e.perciballi

F07. Thomas Vernay, Naicons Laboratories, Milan, Italy
Discovery of novel antibiotics from microbes: a project
Link to poster session: https://campus-unimib.webex.com/meet/t.vernay

15:55 – 16:55 POSTER SESSION and COFFEE BREAK

16:55 – 17:25 TED–like talk and Q&A (T03)
Dott.ssa Giulia de Martini
Humans design technologies and technologies design Humans

17:30 End of day 1

ARTIFICIAL INTELLIGENCE and SYNTHETIC BIOLOGY

Chairs: Riccardo Milanesi, Valentina Artusa

09:00 – 09:45 Invited lecture and Q&A (T04)
Prof. Isak S Pretorius, ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, Australia
The convergence of synthetic biology and artificial intelligence

09:45 – 10:10 PhD student’s presentation: 2nd year (S09)
Luca Mastella, University of Milano-Bicocca, Milan, Italy
Development of a sustainable process to produce Vitamin B9

10:10 – 10:35 PhD student’s presentation: 3rd year (S10)
Giulia Agostinetto, University of Milano-Bicocca, Milan, Italy
Convergent technologies in metagenomics: enhancing the available analytical tools

10:35 – 11:00 PhD student’s presentation: 2nd year (S11)
Letizia Maestroni, University of Milano-Bicocca, Milan, Italy
A novel combination of synthetic biology approaches towards Glucobrassicin production in yeast chassis

11:00 – 11:30 COFFEE BREAK

11:30 – 11:55 PhD student’s presentation: 3rd year (S12)
Nicola Tommasi, University of Milano-Bicocca, Milan, Italy
A multilevel approach to investigate the impact of anthropogenic stressors on pollinator insects in three continents: problems and possible solutions

11:55 – 12:20 PhD student’s presentation: 2nd year (S13)
Davide Panzeri, University of Milano-Bicocca, Milan, Italy
Bowman-Birk protease inhibitor: from phylogenetic diversity to functional efficacy

12:20 – 12:45 PhD student’s presentation: 3rd year (S14)
Alessandra De Giani, University of Milano-Bicocca,Milan, Italy
Impact of prebiotics and probiotics on gut microbiota and human health

12:45 – 13:45 LUNCH BREAK

Chairs: Erika Casari, Gloria Campioni

13:45 – 14:10 PhD student’s presentation: 2nd year (S15)
Roberta Torinesi, University of Milano-Bicocca, Milan, Italy
Stress-induced ubiquitin-rich aggregates: identification and visualization in the yeast Saccharomyces cerevisiae

14:10 – 14:35 PhD student’s presentation: 3rd year (S16)
Fabrizio Beltrametti, BioC-CheM Solution Srl, Gerenzano (VA), Italy
Production and purification of biosurfactants from environmental isolates of fungi and bacteria

14:35 – 15:00 PhD student’s presentation: 2nd year (S17)
Alex Pessina, University of Milano-Bicocca, Milan, Italy
Revisiting trehalose production in yeast

14:35 – 15:10 PhD students’ flash poster presentation: 1st year

F08. Michela Galli, University of Milano-Bicocca, Milan, Italy
Genetic interaction between Mec1 and Mrc1 in response to replication stress
Link to poster session: https://campus-unimib.webex.com/meet/m.galli50

F09. Giulia Motta, University of Milano-Bicocca, Milan, Italy
Adverse outcome pathways-oriented toxicology in in vitro systems for implementing the safety-by-design of new nanomaterials: preliminary studies on Ag NPs
Link to poster session: https://campus-unimib.webex.com/meet/g.motta15

F10. Stefania Pagliari, University of Milano-Bicocca, Milan, Italy
Development of innovative green procedure for the recovery of active compounds from food and agricultural by-products
Link to poster session: https://campus-unimib.webex.com/meet/s.pagliari2

F11. Emiliano Pioltelli, University of Milano-Bicocca, Milan, Italy
Unraveling the impact of urbanization on insect pollinators and their role in shaping fruit chemical features
Link to poster session: https://campus-unimib.webex.com/meet/e.pioltelli

F12. Paolo Pizzul, University of Milano-Bicocca, Milan, Italy
Role of the DNA damage response in R-Loops recognition and signalling
Link to poster session: https://campus-unimib.webex.com/meet/p.pizzul

F13. Marta Simonetti, Albini Group - Cotonificio Albini S.p.A., Albino (BG), Italy
New perspectives for textile waste: recycling material by mechanical/chemical pre-treatment and enzymatic hydrolysis processes
Link to poster session: https://campus-unimib.webex.com/meet/m.simonetti12

F14. Giulia Tomaino, University of Milano-Bicocca, Milan, Italy
Development and characterization of vault-based nanocarriers in Pichia pastoris
Link to poster session: https://campus-unimib.webex.com/meet/g.tomaino3

15:10 – 16:10 POSTER SESSION and COFFEE BREAK

16:10 – 16:40 TED-like talk and Q&A (T05)
Dott. Joseph Sassoon
About Storytelling and Artificial Intelligence

16:40 - 16:50 Spotlight on PhD Students
Valentina Artusa, Stefania Blasa, Fabrizio Beltrametti, Gloria Campioni, Sofia Magli and Nicola Tommasi

16:50 End of day 2

Chairs: Stefania Blasa, Fabrizio Beltrametti

09:00 – 09:25 PhD student’s presentation: 2nd year (S18)
Sara Bertuzzi, CIC bioGUNE, Basque Research Technology Alliance, Derio, Spain
Cross-linking effects dictate the preference of galectins to bind LacNAc-derived HMPA copolymers

09:25 – 09:50 PhD student’s presentation: 3rd year (S19)
Daniele D’Arrigo, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Osteoarthritis theranostics: characterization of synovial fluid extracellular vesicles and an osteoarthritic joint-on-chip model

09:50 –10:15 PhD student’s presentation: 2nd year (S20)
Stefania Garbujo, University of Milano-Bicocca, Milan, Italy
Synthesis and characterization of cell-derived biomimetic nanoparticles and their potential for the investigation of Cancer Associated Fibroblasts (CAFs) function

10:15 – 10:40 PhD student’s presentation: 2nd year (S21)
Lorenzo Rossi, University of Milano-Bicocca, Milan, Italy
Multimodal polymeric nanoparticles for in vivo imaging of pancreatic islets

10:40 – 11:10 COFFEE BREAK

11:10 – 11:40 Invited lecture (2^ part) and Q&A    T01-second part
Prof. Paolo Soda, Biomedical Campus University, Rome, Italy
Bio-image informatics: empowering humans’ skills by machine learning

11:40 – 12:05 PhD student’s presentation: 3rd year (S22)
Riccardo Milanesi, University of Milano-Bicocca, Milan, Italy
Convergent technologies on eukaryotic and prokaryotic central carbon metabolism

12:05 – 12:30 PhD student’s presentation: 2nd year (S23)
Lucia Morelli, University of Milano-Bicocca, Milan, Italy
The advantages of microfluidics technology for nanoparticles continuous manufacturing designed for oral delivery systems

12:30 – 12:55 PhD student’s presentation: 3rd year (S24)
Sofia Magli, University of Milano-Bicocca, Milan, Italy
Biopolymer-based hydrogels as multifunctional 3D printable bio-ink for tissue engineering applications

12:55 – 14:00 LUNCH BREAK

WORKSHOP

14:00 – 17:00 Workshop
T10. Prof. Laura Formenti & Dott. Andrea Galimberti
Department of Human Sciences for Education, University of Milano-Bicocca, Milan, Italy
Developing a professional identity along the PhD training: issues, struggles, possibilities

17:00 – 17:30 Poster award and Greetings
Prof. Paola Branduardi & Organising committee

17:30 End of day 3