From genes to metabolites through proteins: dealing with human health and disease
Youtube: http://s.unimib.it/huzmanheath
Scientific Program
09.50-10.00 Opening Remarks
10.00-11.00 Session 1-Metabolic rewiring in cancer cells. Basic mechanisms and new therapeutic targets (Part I)
Chairs: Iris Chiara Salaroglio and Michela Corsini
10.00-10.15 Unveiling Metabolic Plasticity of Human Osteosarcoma Cells to Improve Cancer Therapy. Francesca Agriesti. University di Foggia
10.15-10.30 Cladosporols Negatively Regulate 3T3-L1 Cell Differentiation and, through Adipocytokine Synthesis and Secretion, Influence HT-29 Colon Carcinoma Cell Proliferation. Roberta Rapuano. Sannio University, Benevento
10.30-10.45Dysregulated Expression of the Transcriptional Factor Gata-1 Rewires Metabolic Activity in Myeloid Leukemia Cells. Silvia Trombetti. University of Naples Federico II
10.45-11.00 MCJ/DNAJC15 Mitochondrial Chaperone as a Metabolic “Balance Needle” in Ovarian Cancer Chemoresistance. Stefano Miglietta. University of Bologna
11.00-11.30 Coffee Break
Chair: Ferdinando Chiaradonna
11.30-12.00 Invited lecture Sex and Gender Dimension in Science and Research. Susanna Chiocca. European Institute of Oncology, Milano
12.00-13.00 Session 2-Metabolism and epigenetic interplay in cancer
Chairs: Elisabetta Aldieri and Anna Privitera
12.00-12.15 Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer. Luigi Ippolito. University of Florence
12.15-12.30 Integrative Analysis of Aberrant Epigenetic Features in Triple Negative Breast Cancer Clinical Samples. Giulia Robusti. European Institute of Oncology, Milano
12.30-12.45 A Key Silencing Histone Mark on Chromatin is Lost when Colorectal Adenocarcinoma Cells Are Depleted in Methionine by Methionine ꝩ-Lyase. Samanta Raboni. University of Parma
12.45-13.00 Novel Insights into DJ-1: a Key Player in Epigenetic Misregulation in Breast Cancer. Marina La Chimia. University of Catanzaro
13.00-14.00 Lunch
14.00-15.00 Poster Session
Chair: Sergio Giannattasio
15.00-15.30 Invited lecture Tackling Tumor Cell Metabolism through a Novel Signaling Pathway Converging on PP2A. Saverio Minucci. University of Milano
15.30-17.00 Session 3-Metabolic rewiring in cancer cells. Basic mechanisms and new therapeutic targets (Part II)
Chairs: Marina Bacci and Luigi D’Angelo
15.30-15.45 A New Immunocompetent Organ on Chip for Modeling the 3D Tumor Microenvironment with Capillary Flow-Driven Immune Cells. Silvia Scaglione. National Research Council, Genoa
15.45-16.00 Riboregulation of Human Serine Hydroxymethyltransferase Activity in Cellular Metabolism. Francesca Romana Liberati. University of Sapienza, Rome
16.00-16.15 Cytotoxic Effect of the Antipsychotic Drug Spiperone in Colorectal Cancer Cells via Endoplasmic Reticulum Stress Induction, Intracellular Lipids Dysregulation, and Golgi Apparatus Damage. Annamaria Antona. University of Piemonte Orientale, Novara
16.15-16.30 SKP2 Drives the Sensitivity to Neddylation Inhibitors and Cisplatin in Malignant Pleural Mesothelioma. Joanna Kopecka. University of Torino
16.30-16.45 From glutamine addiction to altered ROS levels: VEGFR2-dependent metabolic changes in melanoma cells suggest novel therapeutic opportunities. Elisabetta Grillo. University of Brescia
16.45-17.00 Inhibition of Hexosamine Biosynthetic Pathway increases the Gemcitabine effect in pancreatic cancer treatment. Barbara Zerbato. University of Milano Bicocca
17.00-17.10 Awards and Closing remarks
Short talk commission awards: Jlenia Brunetti (Siena), Ilaria Dando (Verona), Alessio
Paone (Roma), Annapina Russo (Napoli)
Poster commission awards: Daniela Capello (Piemonte Orientale), Virginia Di Bella
(Catania), Chiara Giacomelli (Pisa), Laura Patrussi (Siena)