Krenn Veronica

Collaborator - Human Technopole Early Career Fellow

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KRENN VERONICA BtBs UNIMIB

 

room 1016, building U3, tel. +39 02 6448 3052

lab 5040, building U4, tel. +39 02 6448 3514

veronica.krenn@unimib.it

see also: ResearcherID (publons), ORCID, LinkedinTwitter, Scopus

Research Group

Cascio Anna – Postgraduate Fellow
lab 5040, building U4, tel. +39 02 6448 3514
anna.cascio@unimib.it

Background

Veronica Krenn graduated cum Laude in Biotechnologies at the University of Milano-Bicocca, Italy, and received a PhD in Molecular Medicine at the University of Milano, with an internship at the Institute of Experimental Oncology (IEO), working on human mitotic division in the Musacchio laboratory.

She moved to the Max-Planck Insitute of Molecular Physiology in Germany during her PhD and later to the Knoblich laboratory at the Vienna BioCenter as Post-Doc, where she started to work on human brain organoid systems. She joined our department in 2022, after being awarded with the Early Career Fellowship promoted by the Human Technopole.

Keywords

Brain development, cerebral organoids, iPSCs, microglia, neuroinflammation, genetic diseases, congenital infections

Research interest

The lab uses stem cells - derived models to investigate the molecular basis of neuroimmune interactions regulating brain development and their alterations in disease conditions

Research projects

-A human organoid-based culture of Central nervous system-Associated Macrophages (CAM) for functional study of -neurodevelopment and disease
Anno: 2023
Bando: FAQC 2023 - prima finestra
Enti finanziatori: Università degli Studi di MILANO-BICOCCA

-Human Neuroimmunobiology Project - The project aims at developing human stem cells- derived 2D and 3D cellular models to study the mechanisms of neuroimmunological dysfunction and their contribution to the pathogenesis of neurodevelopmental disorders.
Anno: 2021
Enti finanziatori: FONDAZIONE HUMAN TECHNOPOLE

Selected articles

-Krenn, V., Bosone, C., Burkard, T.R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Rilo Christoff, R., Pestana Garcez, P., Mirazimi, A., Knoblich, J.A. 2021 Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly. Cell Stem Cell 28, 1362–1379.e7. doi:10.1016/j.stem.2021.03.004

-Bajaj, S., Bagley, J.A., Sommer, C., Vertesy, A., Nagumo Wong, S., Krenn, V., Lévi-Strauss, J., Knoblich, J.A., 2021. Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration. EMBO J. 40, e108714. doi:10.15252/embj.2021108714

International and national collaborations

National collaborations:

Prof. Silvia Nicolis, Università degli Studi di Milano-Bicocca (UNIMIB)

Prof. Giuseppe Testa, Human Technopole

International collaborations:

Prof. Jürgen Knoblich, IMBA -Vienna

Dr. Christopher Esk, University of Innsbruck


Krenn’s Lab – #KrennLab_BtBs
last update June 2022

Salvioni Lucia, PhD

Assistant Professor

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Salvioni Lucia_BtBs UNIMIB

 

lab 2011, building U3, tel. +39 02 6448 3395

see also: PubMed, ResearchGate, GoogleScholar, Scopus, Linkedin

lucia.salvioni@unimib.it

My research activity is devoted to the world of nanobiotechnology: this includes several multidisciplinary activities like the development of nanodrug delivery systems, the study of novel nano-based contrast agents, the formulation design as well as the investigation of interaction between nanomaterials and biological systems.

I am part of a multidisciplinary research group named NanoBioLab.
https://nanobiolab.it/ ; https://www.instagram.com/nanobiolab/

Keywords

Nanomedicine, Nanobiotechnology, Nanomaterials, Drug delivery, Imaging, Formulations, Cancer, Infections and Inflammation

Research interest

Nanodelivery of biological drugs
Biological drugs include a wide range of active ingredients such as peptides, proteins, genetic materials, whose application is strongly impaired by their poor stability, low permeability and rapid body clearance. The use of nano-based drug delivery systems may overcome these drawbacks and open up new possibility for treatment of several disorders (e.g., cancer, infections, metabolic disorders).

Nanomaterials for diagnostic purposes
The early diagnosis is the key for successfully treating several disorders including cancer. One major need in the field of medical imaging is to increase the specificity and the sensitivity of contrast agents. In this scenario, engineered nanomaterials can be developed for directing contrast agents in specific regions and improve the detection of malignant masses.

Study of Nano-Bio Interactions
Several scientists have pointed out that lack of knowledge in the interaction of nanomaterials with biological systems can seriously limit nanotechnology potential. Thus, part of my research activity aims to give a contribution to this field by investigating nanoparticles intracellular trafficking, their capability of crossing the biological barriers, nanotoxicology or their potential antimicrobic effect.

Development of solid and semisolid formulations
The majority of the new products based on nanomaterials are administered by parenteral injection. However, the use of alternative administration routes may open up new possibilities and better meet the need of the patients in terms of compliance. Thus, part of my research activity is focused on the study of formulation of drug and nanodelivery systems in semisolid and solid dosage forms for pharmaceutical and cosmetic purposes.

Selected articles

Saporin Toxin Delivered by Engineered Colloidal Nanoparticles Is Strongly Effective against Cancer Cells
L. Salvioni, F Testa, L. Barbieri, M. Giustra, J. A. Bertolini, G. Tomaino, P. Tortora, D. Prosperi, M. Colombo
Pharmaceutics. 2022, 14 (7), 1517. https://doi.org/10.3390/pharmaceutics14071517

Development of an effective tumor-targeted contrast agent for Magnetic Resonance Imaging based on Mn/H-Ferritin nanocomplexes
C. Tullio†, L. Salvioni†, M. Bellini, A. Degrassi, L. Fiandra, S Garbujo, R. Rotem, F. Testa, D. Prosperi, M. Colombo
ACS applied biomaterials and interface.  2021, 4(11), 7800–7810. https://doi.org/10.1021/acsabm.1c00724

Impact of Tuning the Surface Charge Distribution on Colloidal Iron Oxide Nanoparticle Toxicity Investigated in Caenorhabditis elegans
L. Amigoni†, L. Salvioni†, B. Sciandrone, M. Giustra, C. Pacini, P. Tortora, D. Prosperi, M. Colombo, M.E. Regonesi. Nanomaterials. 2021, 11(6), 1551. https://doi.org/10.3390/nano11061551    

The emerging role of nanotechnology in skincare
L. Salvioni, L. Morelli, E. Ochoa, M. Labra, L. Fiandra, L. Palugan, D. Prosperi, M. Colombo
Advances in Colloid and Interface Science. 2021, 293. https://doi.org/10.1016/j.cis.2021.102437

Nanoparticle-Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment
L. Salvioni, S. Zuppone, F. Andreata, M. Monieri, S. Mazzucchelli, C. Di Carlo, L. Morelli, C. Cordiglieri, L. Donnici, R. De Francesco, F. Corsi, D. Prosperi, R. Vago, M. Colombo
Advanced Therapeutics. 2020, 3(8). https://doi.org/10.1002/adtp.202000007

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope
L. Salvioni†, M.A. Rizzuto†, J.A. Bertolini, L. Pandolfi, M. Colombo, D. Prosperi.
Cancers (Basel). 2019, 11(12). https://doi.org/10.3390/cancers11121855

Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations
L. Salvioni, E. Galbiati, V. Collico, G. Alessio, S. Avvakumova, F. Corsi, P. Tortora, D. Prosperi, M. Colombo.
International Journal of Nanomedicine. 2017, 12, 2517–2530. https://doi.org/10.2147/IJN.S127799

Oral delivery of insulin via polyethylene imine-based nanoparticles for colonic release allows glycemic control in diabetic rats
L. Salvioni, L. Fiandra, M.D. Del Curto, S. Mazzucchelli, R. Allevi, M. Truffi, L. Sorrentino, B. Santini, M. Cerea, L. Palugan, F. Corsi, M. Colombo.
Pharmacological Research. 2016, 110, 122–130, https://doi.org/10.1016/j.phrs.2016.05.016

† equally contributed


Salvioni’s Lab – #SalvioniLab_BtBs
last update: December
2022

Legnani Laura, PhD

Assistant Professor in Organic Chemistry

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room 1016, building U3-BIOS, tel.: +39 02 6448 3420

laura.legnani@unimib.it

Keywords

Organic chemistry, Molecular modeling, DFT calculations, mechanistic investigations, pericyclic reactions

Research interest

Study of bio-active compounds with related bio-organic problems and mechanistic studies of organic reactions are performed through computational approaches.

International and national collaborations

Prof. Pedro Merino – Instituto de Síntesis Quimica y Catalisis Homogenea, Universidad de Zaragoza, Spagna

Prof. Maria Assunta Chiacchio – Dipartimento di Scienze del Farmaco e della Salute, Università di Catania

Prof. Giuseppe Trusso Sfrazzetto, Dipartimento di Scienze del Farmaco e della Salute, Università di Catania


Legnani’s Lab – #LegnaniLab_BtBs
last update: June
2022