BtBs seminar - Nanoscale Control of the Heartbeat - Biophysics Week 2025 Affiliate Event

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William Louch, University of Oslo, Norway. Thursday 27 March 2025, 4:30 pm, BIOS-U3 building, room U3-04 and Webex

Seminar - Biotechnology and Biosciences - Thursday 27 March 2025, 4:30 pm, BIOS-U3 building, room U3-04 and Webex

Biophysics Week 2025 Affiliate Event

 

William Louch, University of Oslo, Norway

Louch group

Abstract

Image
Seminari-BtBs-UNIMIB

Contraction of the heart is reliant on the shortening of individual cardiomyocytes, elicited by Ca2+ release at sub-cellular structures called dyads. However, the precise arrangement and function of dyads remains unclear, both in health and disease. Our work has examined this critical question using emerging microscopy techniques, including live-cell super-resolution (PALM) imaging. Our results show that nanoscale changes in dyadic structure promote fine-tuning of Ca2+ release in health, but deranged Ca2+ homeostasis during heart failure. These data suggest that newfound regulators of dyadic structure and function may serve as novel therapeutic targets in this disease.

Host: Antonio Zaza, Francesco Lodola

The seminar will also be streamed on Webex
https://unimib.webex.com/unimib-it/j.php?MTID=m361b4ee63abdc8da55337e9dcb010325

Password: day27

for information:  infobtbs@unimib.it


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