BtBs seminar - Protein Folding Pathways Across Physiology & Therapy

Emiliano Biasini,  University of Trento

Advanced computational methods have allowed us to define a novel drug discovery paradigm, called PPI-FIT, to suppress protein expression by acting on folding pathways. To translate such a conceptual framework to physiological contexts, we assessed the solvent accessibility of 87,138 modified residues in the human proteome and discovered that one-third of phosphorylated proteins have phosphosites buried within their core. These cryptic phosphosites likely become exposed during folding, influencing protein expression. Our findings re-define the intricate regulatory landscape of protein folding and open up possibilities for therapeutic interventions.

Host: Francesco Peri

The seminar is OPEN to all.

per informazioni:  infobtbs@unimib.it

search:   #BtBsSeminar  ,   #BtBsUNIMIB  ,  #BtBsSeminars ,  #PeriLab_BtBs