Seminar - Biotechnology and Biosciences - Thursday, October 2, 2025, 4:30 PM, BIOS-U3 building, TBA room
Marina Mapelli, European Institute of Oncology
Abstract
In multicellular organisms, the execution of developmental and homeostatic programs relies on asymmetric cell divisions orchestrated by signals from the niche presented in a directional manner, such as Wnt signals. Here we employ bioengineered Wnt-niches to demonstrate that in metaphase NuMA/dynein microtubule motors form a complex with LRP6 and b-catenin at the cortical sites of Wnt activation to orient cell division perpendicularly. Additionally, we developed a proteomic-based approach to identify mitotic protein complexes enriched at the Wnt-contact site, revealing that mitochondria polarize toward localized Wnt3 sources and in mESC are asymmetrically apportioned to the Wnt-proximal daughter. Our findings elucidate fundamental principles underlying Wnt-dependent mitochondrial polarization.
Host: Veronica Krenn
The seminar is OPEN to all.
ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.
The seminar's online registration will be available a few days before the event.
for information: infobtbs@unimib.it
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