Seminar - Biotechnology and Biosciences - Thursday, November 30, 2023, 4.30 pm, U3-BIOS building, room U3-10 / Webex
Valentina Rossio, Cell Biology Department, King Lab, Harvard Medical School, Boston
Abstract
Deubiquitylating enzymes (DUBs) regulate many cellular processes. Our understanding of DUB-substrate specificity is limited because DUBs are typically not compared to each other against large numbers of physiological substrates. We developed a quantitative proteomic approach to compare DUB activity on hundreds of ubiquitylated proteins in Xenopus egg extract. We uncovered interesting aspects of DUB specificity and candidate substrates for many DUBs, which pinpoint novel biological function for these enzymes. We also observed that candidate substrates were enriched for disordered regions compared to proteins insensitive to DUBs, suggesting this feature may promote DUB recognition.
Host: Roberta Fraschini
LINK to participate in the seminar: https://unimib.webex.com/unimib-it/j.php?MTID=m75ad328b2b6cba49b729a55f9cd62204
password: day30 (32930 da telefoni e sistemi video)
The seminar is OPEN to everyone.
tag: #BtBsSeminars , #FraschiniLab_BtBs