BtBs seminar - Clonal evolution in leukaemia: timing of immune escape and marker plasticity

Giulio Caravagna, Università degli Studi di Trieste.

Liquid cancers have always been one of the primal examples of the application of the clonal evolution model by Nowell. Our group studied these cancers over the last few years, focusing on their behaviour under standard treatment scenarios (immunotherapy and targeted therapy). In this talk, I will overview two large applications of our computational studies on leukaemia evolution. I will concentrate on AMLs and CLLs, identifying the timing of immune evasion after allogenic transplant in AMLs, and determining the plasticity of a prognostic marker for CLLs. To reach these results, we developed advanced modelling and statistical inference frameworks, combining stochastic processes modelling from different angles, as well as Bayesian inference techniques applied to longitudinal whole-genome sequencing data.

Host: Chiara Damiani

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

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