Biotechnology and Biosciences Seminar - Thursday, May 25, 2023, 4:30 pm, BIOS Building, Room U3-08 / Webex
Jose Maria Ferrero ‐ Department of Electronic Enginering, Universitat, Politècnica de València
Jose Felix Rodriguez Matas ‐ Dipartimento di chimica, materiali e ingegneria chimica “Giulio Natta”, Politecnico di Milano
Abstract
Acute myocardial ischemia induces hyperkalemia, a major perpetrator of reentrant ventricular arrhythmias. Despite considerable experimental efforts to explain this pathology, the mechanisms behind hyperkalemia remain partially unknown. We developed a novel computational model of acute myocardial ischemia that couples an electrophysiologically detailed human cardiomyocyte model accounting for ischemia induced changes in transmembrane currents, with a model of cardiac tissue and extracellular K+ transport. The model reproduces and explain the triphasic time course of extracellular K+ concentration within the ischemic zone, and the formation of a [K+]o border zone after the onset of ischemia
Host: Antonio Zaza e Francesco Lodola
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LINK to attend the seminar: https://unimib.webex.com/unimib-it/j.php?MTID=ma098d833dd7b029aa9f1ea19b4e421cc
password: day25 (32925 da telefoni e sistemi video)
The seminar is OPEN to all.
tag: #BtBsSeminars , #ZazaLab_BtBs , #LodolaLab_BtBs