BtBs seminar - Temporal regulation of human neurodevelopment in human pluripotent stem cells-based models

Gabriele Ciceri, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget).

Brain development follows sequential steps that instruct the assembly of distinct cell types in space and time. Human pluripotent stem cells (hPSC) recapitulate developmental trajectories during differentiation. A remaining challenge is how to control for timing, which is highly protracted in humans and is largely retained in vitro during hPSC differentiation. I will present recent efforts on novel tractable hPSC-based approaches capturing the progression of human neurodevelopment at high precision. These studies converge on identifying an epigenetic program setting timing, whose experimental manipulation allows to modulate the pace of hPSC cell-fate specification and neuronal maturation.

Host: Veronica Krenn

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

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