Seminar - Biotechnology and Biosciences - Thursday, December 11, 2025, 4:30 PM, TELLUS-U4 building, room U4-04
Antonino Bruno, Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry and Immunology, IRCCS MultiMedica, Milan, Italy; Laboratory of General Pathology and Immunology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Abstract
Natural killer (NK) cells are innate lymphoid cells capable of controlling tumor growth and dissemination. However, tumor cells and the related tissue microenvironment can affect NK cell anti- tumor activities by limiting their infiltration in the tumor mass or by generating hypofunctional/anergic/exhausted NK cells.
We will discuss the major mechanisms governing NK cell immune-escape, while we will focus on a new NK cell subset, identified in solid tumors, endowed with pro-tumor and pro-angiogenic features, namely decidual-like NK cells.
Finally, we will discuss major strategy to re-educate the anti tumor activities of NK cells, in solid cancer, including some drug repurposing approaches.
Host: Silvia Barabino
The seminar is OPEN to all.
ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.
The seminar's online registration will be available a few days before the event.