BtBs seminar - Maintaining Neuronal Homeostasis: The Role of Autophagy in Health and Disease

Michela Palmieri, Rett syndrome and neurodevelopmental disorders Unit, Università Vita Salute San Raffaele.

Neuronal homeostasis is fundamental to brain function, integrating mechanisms that regulate neuronal differentiation, synaptic connectivity, neurotransmission, and survival throughout life. Our research investigated the molecular mechanisms underlying neuronal and synaptic homeostasis during cortical development and aging, with a particular focus on autophagy and its contribution to neurodevelopmental disorders (NDDs), including Rett syndrome (RTT). We demonstrated that the precise developmental regulation of autophagic pathways is essential for proper cortical maturation, while its disruption contributes to RTT pathology. Furthermore, restoring autophagy-lysosomal function ameliorated neurological phenotypes in a Rett syndrome model. By combining transcriptomic, proteomic, and molecular approaches, we uncovered dynamic shifts in autophagy-related pathways during corticogenesis and identified key synaptic components involved in circuit maturation. Collectively, our findings offer new insights into the cellular mechanisms governing brain homeostasis and their implication in NDDs.

Host: Silvia Barabino

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

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