BtBs seminar - Modeling glucose metabolism with FSDEs

Andrea De Gaetano, Istituto per la Ricerca e l'Innovazione Biomedica del CNR (CNR-IRIB, Palermo)

Complex biological phenomena, of very concrete interest from a biomedical point of view, lend themselves to mathematical modeling. The clinical practitioner would like to extract meaningful features from available data, leading to potential adjustments in diagnosis, prognosis or therapy. However, it often happens that the available clinical data, even if abundant in quantity, carry a modest information content, making detailed models unidentifiable. This is the case, for example, of trans-cutaneously measured glycemia, where besides glycemia itself (possibly decaying by first-order elimination) also unobserved factors (insulinemia, other hormones) may exert higher order effects. The problem is here further complicated by the fact that random events (food intake, exercise, emotions) may affect glycemia as well. Standard mathematical modeling tools are inadequate to deal with this kind of problems. This presentation will exemplify the use of simple Fractional Stochastic Differential Equation (FSDE) models of glycemic control, with the attendant approaches to parameter estimation in this framework.

Host: Pasquale Palumbo

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

search:   #BtBsSeminar  ,   #BtBsUNIMIB  ,  #BtBsSeminars