BtBs seminar - RNA Metabolism Defects and Premature Ageing in Saccharomyces cerevisiae

Cristina Mazzoni, Department of Biology and Biotechnology ‘‘Charles Darwin’’, Sapienza University of Rome.

Saccharomyces cerevisiae serves as a model to study human cellular processes, such as aging and programmed cell death, owing to conserved eukaryotic pathways.
LSM (SM-like) mutants (e.g., lsm4Δ1) are valuable tools for aging research because they exhibit premature aging phenotypes, such as shorter lifespans, stress sensitivity, and increased cell death, making them excellent models for studying aging mechanisms, RNA metabolism disruption, protein aggregate clearance (proteostasis), and the efficacy of potential anti-aging conditions and compounds. These mutants were used to understand how defects in RNA processing and degradation (linked to LSM proteins) lead to cellular dysfunction and accelerated aging, often involving compromised autophagy and oxidative stress.

Host: Sonia Colombo

The seminar is OPEN to all.

ONLINE REGISTRATION for the seminar is a mandatory requirement for those who wish to request the CERTIFICATE OF ATTENDANCE, which, together with the signature on the ATTENDANCE SHEET, will confirm actual participation.

The seminar's online registration will be available a few days before the event.

for information:  infobtbs@unimib.it

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