Seminar - Biotechnology and Biosciences - Thursday 28 March 2024, 4.30pm, U4-TELLUS building, room U4-01
Martino Introna, Center of Cellular Therapy "G. Lanzani", ASST Papa Giovanni XXIII, Bergamo
Abstract
Acute lymphoblastic leukemia patients experience relapse after several lines of treatment and even after allogeneic transplantation. In order to cope with this devastating disease, we have traditionally used donor derived lymhocytes, often problematic for the difficulties to treat acute versus graft disease. In order to try and ameliorate the destiny of these patients, we have produced a T cell receptor (CAR molecule) against the CD19 surface protein and used this technology by transposon mediated gene transfer. Clinical and experimental data will be shown to demonstrate the feasibility, safety and clinical activity of such approach in our Academic environment, including a GMP compliant cell factory.
Host: Francesca Granucci
The seminar is OPEN to everyone.
Webex connection NOT available
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